Yang Ronghua, Wang Jingru, Chen Xiaodong, Shi Yan, Xie Julin
Department of Burn Surgery, The First People's Hospital of Foshan, Foshan 528000, China.
Department of Medical Cosmetology, Jiangxi Maternal and Child Health Hospital, Nanchang 330006, China.
Stem Cells Int. 2020 Jan 29;2020:9148310. doi: 10.1155/2020/9148310. eCollection 2020.
Skin stem cells distributed in the basal layer of the epidermis and hair follicles are important cell sources for skin development, metabolism, and injury repair. At present, great progress has been made in the study of epidermal stem cells at the cellular and molecular levels. Stem cell transplantation is reported to promote skin healing, endothelial cell transformation, and vascular formation. Local stem cells can also be transformed into keratinocytes, sebaceous gland, and other skin-associated tissues. However, the mechanism of action of epidermal stem cells on wound healing and regeneration is not completely clear. This review is aimed at briefly summarizing the biological characteristics of epidermal stem cells and their clinical application in wound healing and tissue regeneration. It further discussed the mechanism of action and the development direction in the future.
分布于表皮基底层和毛囊的皮肤干细胞是皮肤发育、新陈代谢及损伤修复的重要细胞来源。目前，表皮干细胞在细胞和分子水平的研究已取得了很大进展。据报道，干细胞移植可促进皮肤愈合、内皮细胞转化及血管形成。局部干细胞也可转化为角质形成细胞、皮脂腺及其他皮肤相关组织。然而，表皮干细胞在伤口愈合和再生中的作用机制尚不完全清楚。本文旨在简要综述表皮干细胞的生物学特性及其在伤口愈合和组织再生中的临床应用，并进一步探讨其作用机制及未来发展方向。
