RNA 聚合酶 II 旧修饰和新修饰的组合视图。
A combinatorial view of old and new RNA polymerase II modifications.
机构信息
Gladstone Institute of Virology and Immunology, San Francisco, CA, USA.
Department of Medicine, University of California, San Francisco , San Francisco, CA, USA.
出版信息
Transcription. 2020 Apr;11(2):66-82. doi: 10.1080/21541264.2020.1762468. Epub 2020 May 13.
Abstract
The production of mRNA is a dynamic process that is highly regulated by reversible post-translational modifications of the C-terminal domain (CTD) of RNA polymerase II. The CTD is a highly repetitive domain consisting mostly of the consensus heptad sequence Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Phosphorylation of serine residues within this repeat sequence is well studied, but modifications of all residues have been described. Here, we focus on integrating newly identified and lesser-studied CTD post-translational modifications into the existing framework. We also review the growing body of work demonstrating crosstalk between different CTD modifications and the functional consequences of such crosstalk on the dynamics of transcriptional regulation.
摘要
mRNA 的产生是一个动态过程，受到 RNA 聚合酶 II 末端结构域 (CTD) 的可逆翻译后修饰的高度调控。CTD 是一个高度重复的结构域，主要由共识七肽序列 Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 组成。该重复序列中丝氨酸残基的磷酸化已得到充分研究，但所有残基的修饰都已被描述。在这里，我们专注于将新鉴定和研究较少的 CTD 翻译后修饰整合到现有框架中。我们还回顾了越来越多的工作，这些工作证明了不同 CTD 修饰之间的串扰以及这种串扰对转录调控动态的功能后果。
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