Mandal Manotosh, Jana Soovoojeet, Nandi Swapan Kumar, Khatua Anupam, Adak Sayani, Kar T K
Department of Mathematics, Tamralipta Mahavidyalaya, Tamluk 721636, West Bengal, India.
Department of Mathematics, Indian Institute of Engineering Science and Technology, Shibpur, Howrah 711103, India.
Chaos Solitons Fractals. 2020 Jul;136:109889. doi: 10.1016/j.chaos.2020.109889. Epub 2020 May 13.
As there is no vaccination and proper medicine for treatment, the recent pandemic caused by COVID-19 has drawn attention to the strategies of quarantine and other governmental measures, like lockdown, media coverage on social isolation, and improvement of public hygiene, etc to control the disease. The mathematical model can help when these intervention measures are the best strategies for disease control as well as how they might affect the disease dynamics. Motivated by this, in this article, we have formulated a mathematical model introducing a quarantine class and governmental intervention measures to mitigate disease transmission. We study a thorough dynamical behavior of the model in terms of the basic reproduction number. Further, we perform the sensitivity analysis of the essential reproduction number and found that reducing the contact of exposed and susceptible humans is the most critical factor in achieving disease control. To lessen the infected individuals as well as to minimize the cost of implementing government control measures, we formulate an optimal control problem, and optimal control is determined. Finally, we forecast a short-term trend of COVID-19 for the three highly affected states, Maharashtra, Delhi, and Tamil Nadu, in India, and it suggests that the first two states need further monitoring of control measures to reduce the contact of exposed and susceptible humans.
由于目前尚无针对新冠病毒的疫苗和有效的治疗药物,由新冠病毒引发的近期疫情使人们开始关注隔离策略以及政府采取的其他措施,如封锁、媒体对社交隔离的报道以及公共卫生的改善等,以控制疫情。数学模型有助于确定这些干预措施何时是控制疾病的最佳策略,以及它们可能如何影响疾病动态。受此启发,在本文中,我们构建了一个引入隔离类别和政府干预措施的数学模型,以减轻疾病传播。我们根据基本再生数研究了该模型的全面动力学行为。此外,我们对基本再生数进行了敏感性分析,发现减少暴露人群与易感人群之间的接触是实现疾病控制的最关键因素。为了减少感染个体数量并使实施政府控制措施的成本最小化,我们提出了一个最优控制问题,并确定了最优控制。最后,我们预测了印度受影响最严重的三个邦——马哈拉施特拉邦、德里和泰米尔纳德邦的新冠疫情短期趋势,结果表明前两个邦需要进一步监测控制措施,以减少暴露人群与易感人群之间的接触。