Zarneshan Azam, Gholamnejad Mahdia
Department of Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran.
Department of Pulmonology, Urmia University of Medical Sciences, Urmia, Iran.
Tanaffos. 2019 Mar;18(3):230-237.
In this study, we aimed to investigate the effects of aerobic exercise training on the serum IL-4/IFN-γ ratio (Th1/Th2 balance), testosterone/cortisol ratio, levels of cortisol, testosterone, estrogen, and progesterone, and body mass index (BMI) and to determine the relationship between changes in these variables in women with asthma.
Twenty-one women with mild to moderate asthma and regular menstrual cycles were selected in this study. Eleven women in the exercise group participated in the aerobic exercise program (60 min/day, three days a week in the evening). Peripheral blood samples were collected before (week 0) and after (week 12) the program. The samples were analyzed to determine the levels of sex hormones and cortisol via chemiluminescence assay, and cytokines were examined by ELISA assay.
The findings showed a significant increase in the Th1/Th2 ratio and a decrease in cortisol and BMI in the exercise group, compared to the control group (P<0.05). There was no significant correlation between changes in cortisol, sex hormones, and BMI and the increase in Th1/Th2 ratio.
The present results suggested that moderate aerobic exercise enhances the Th1/Th2 ratio, independent of changes in steroid hormone level and BMI in women with asthma.
在本研究中，我们旨在调查有氧运动训练对血清白细胞介素-4/干扰素-γ比值（Th1/Th2平衡）、睾酮/皮质醇比值、皮质醇、睾酮、雌激素和孕酮水平以及体重指数（BMI）的影响，并确定哮喘女性这些变量变化之间的关系。
本研究选取了21名轻度至中度哮喘且月经周期规律的女性。运动组的11名女性参加了有氧运动计划（每天60分钟，每周三次，在晚上进行）。在该计划开始前（第0周）和结束后（第12周）采集外周血样本。通过化学发光法分析样本以测定性激素和皮质醇水平，通过酶联免疫吸附测定法检测细胞因子。
研究结果显示，与对照组相比，运动组的Th1/Th2比值显著升高，皮质醇和BMI降低（P<0.05）。皮质醇、性激素和BMI的变化与Th1/Th2比值的升高之间无显著相关性。
目前的结果表明，适度有氧运动可提高哮喘女性的Th1/Th2比值，且与类固醇激素水平和BMI的变化无关。
