RNA N6-Methyladenosine 修饰与免疫应答
RNA N-Methyladenosine Modifications and the Immune Response.
机构信息
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy Medical Science and Peking Union Medical College, Beijing, China.
出版信息
J Immunol Res. 2020 Jan 21;2020:6327614. doi: 10.1155/2020/6327614. eCollection 2020.
Abstract
N-methyladenosine (mA) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of mA modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the mA modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating mA modifications of RNA have developed rapidly. This article reviews the biological significance of RNA mA modifications in the innate immune response, adaptive immune response, and viral infection.
摘要
N6-甲基腺苷（m6A）是高等真核生物信使 RNA（mRNA）和长非编码 RNA（lncRNA）中最重要的修饰。m6A 修饰的调节依赖于甲基转移酶和去甲基酶。结合蛋白的发现证实了 m6A 修饰在分子、细胞和生理水平上具有广泛的生物学效应和意义。近年来，研究 RNA m6A 修饰的技术发展迅速。本文综述了 RNA m6A 修饰在固有免疫应答、适应性免疫应答和病毒感染中的生物学意义。
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本文引用的文献
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Cell. 2019 Jul 25;178(3):515-517. doi: 10.1016/j.cell.2019.07.006.
2
Regulation of Viral Infection by the RNA Modification -Methyladenosine.RNA 修饰——甲基腺苷对病毒感染的调控。
Annu Rev Virol. 2019 Sep 29;6(1):235-253. doi: 10.1146/annurev-virology-092818-015559. Epub 2019 Jul 5.
3
The RNA N-methyladenosine modification landscape of human fetal tissues.人类胎儿组织中 RNA N6-甲基腺苷修饰图谱。
Nat Cell Biol. 2019 May;21(5):651-661. doi: 10.1038/s41556-019-0315-4. Epub 2019 Apr 29.
4
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Nat Commun. 2019 Apr 23;10(1):1858. doi: 10.1038/s41467-019-09712-x.
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Mol Cancer. 2019 Apr 13;18(1):87. doi: 10.1186/s12943-019-1014-2.
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