微小RNA（miRNA）对冠状病毒基因型的影响。
The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses.
作者信息
Canatan Duran, De Sanctis Vincenzo
机构信息
Prof. Dr. Duran Canatan MD Antalya Genetic Diseases Diagnosis Center Arapsuyu Mh. 600 Sk 39/A 07070 Konyaalti, Antalya,Turkey.
出版信息
Acta Biomed. 2020 May 11;91(2):195-198. doi: 10.23750/abm.v91i2.9534.
Abstract
Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is arranged as 5p-replicase (orf1/ab)-structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] -3. Viruses are obligate intracellular infectious agents that use the host cellular machinery to ensure their own fitness and survival. MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. This review focuses to the genomic structure of coronaviruses, the functions of genomic proteins, the effects of micro RNA (miRNA) on virus replication and its pathogenesis.
摘要
总结。2020年初出现了新型冠状病毒肺炎（COVID-19），这是由一种新型冠状病毒严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的疫情，SARS-CoV-2是对人类而言的一种重要病原体。SARS-CoV-2是一种RNA病毒，含有29891个核苷酸，编码9889个氨基酸。基因组排列为5' - 复制酶（orf1/ab）- 结构蛋白[刺突蛋白（S）- 包膜蛋白（E）- 膜蛋白（M）- 核衣壳蛋白（N）]- 3'。病毒是专性细胞内感染因子，利用宿主细胞机制来确保自身的适应性和存活。微小RNA（miRNA）系统是强大的转录后基因表达调节因子，是病毒感染的重要调节因子，并且可能在病毒感染治疗中发挥重要作用。本综述重点关注冠状病毒的基因组结构、基因组蛋白的功能、微小RNA（miRNA）对病毒复制及其发病机制的影响。
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