Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Department of Family and Community Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Int J Environ Res Public Health. 2020 May 16;17(10):3478. doi: 10.3390/ijerph17103478.
(1) Background: Early life exposure to neurotoxic chemicals can have later impacts on child health. Most research designs must assume that current exposure is similar to past. Life history calendar methods can help to provide data on early life exposure. (2) Methods: Life history calendars were completed by mothers of 8-year-old children from Latinx farmworker and non-farmworker families ( = 73 and 65, respectively). Measures were created of months exposure through living adjacent to farm fields and having household members who worked in jobs exposing them to toxic chemicals. Data were divided into time periods of in utero, early childhood (birth-35 months) and later childhood (36-96 months). Cluster analysis compared the measures for children from farmworker and non-farmworker parents. (3) Results: Although, as a group, children from farmworker families have greater lifetime months of probable exposure to pesticides than children in non-farmworker families, cluster analysis reveals groups of children who do not follow that pattern. (4) Conclusions: The life history calendar is a technique for obtaining data on early life toxic chemical exposure that may help assign children to proper exposure groups. Conducting secondary analyses using such information can help to clarify the association of exposures to health outcomes.
(1) 背景：儿童在生命早期接触神经毒性化学物质可能会对其后期健康产生影响。大多数研究设计都必须假设当前的暴露与过去相似。生活史日历方法可以帮助提供关于生命早期暴露的数据。
(2) 方法：拉丁裔农场工人和非农场工人家庭的 8 岁儿童的母亲（分别为 73 名和 65 名）填写了生活史日历。通过与农田相邻居住和家中有从事接触有毒化学物质工作的家庭成员，来衡量在子宫内、幼儿期（出生至 35 个月）和儿童后期（36-96 个月）的接触月数。聚类分析比较了来自农场工人和非农场工人父母的孩子的措施。
(3) 结果：尽管作为一个整体，来自农场工人家庭的孩子一生中可能接触农药的月数比非农场工人家庭的孩子多，但聚类分析揭示了一些不符合这种模式的孩子群体。
(4) 结论：生活史日历是一种获取生命早期有毒化学物质暴露数据的技术，它可以帮助将儿童分配到适当的暴露组。使用此类信息进行二次分析可以帮助阐明暴露与健康结果之间的关联。
