• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation.

作者信息

Mirams Gary R, Niederer Steven A, Clayton Richard H

机构信息

School of Mathematical Sciences, University of Nottingham, Mathematical Sciences Building, University Park, Nottingham, Nottinghamshire NG7 2RD, UK.

Division of Imaging Sciences and Biomedical Engineering, Kings College London, The Rayne Institute, 4th Floor, Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.

出版信息

Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20200119. doi: 10.1098/rsta.2020.0119. Epub 2020 May 25.

DOI:10.1098/rsta.2020.0119
PMID:32448073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7287327/
Abstract
摘要

相似文献

1
The fickle heart: uncertainty quantification in cardiac and cardiovascular modelling and simulation.善变之心：心脏及心血管建模与模拟中的不确定性量化
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20200119. doi: 10.1098/rsta.2020.0119. Epub 2020 May 25.
2
HeMoLab--Hemodynamics Modelling Laboratory: an application for modelling the human cardiovascular system.HeMoLab--血液动力学建模实验室：用于建模人体心血管系统的应用程序。
Comput Biol Med. 2012 Oct;42(10):993-1004. doi: 10.1016/j.compbiomed.2012.07.011. Epub 2012 Sep 8.
3
A review of cardiovascular anatomy and physiology.心血管解剖学与生理学综述。
Am J Pharm Sci Support Public Health. 1972 Mar-Apr;144(2):54-64.
4
Generalized polynomial chaos-based uncertainty quantification and propagation in multi-scale modeling of cardiac electrophysiology.基于广义多项式混沌的不确定性量化与传播在心脏电生理多尺度建模中的应用。
Comput Biol Med. 2018 Nov 1;102:57-74. doi: 10.1016/j.compbiomed.2018.09.006. Epub 2018 Sep 15.
5
[Anatomy and physiology in word and image "the cardiovascular system"].[图文并茂的解剖学与生理学“心血管系统”]
Kinderkrankenschwester. 2003 Feb;22(2):58-61.
6
Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology.心脏电生理学多尺度模型中快速钠电流稳态失活的不确定性量化
Prog Biophys Mol Biol. 2015 Jan;117(1):4-18. doi: 10.1016/j.pbiomolbio.2015.01.008. Epub 2015 Feb 7.
7
An audit of uncertainty in multi-scale cardiac electrophysiology models.多尺度心脏电生理学模型不确定性的审核。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190335. doi: 10.1098/rsta.2019.0335. Epub 2020 May 25.
8
Cardiovascular asymmetries and cardiac perception.心血管不对称与心脏感知。
Int J Neurosci. 1988 Mar;39(1-2):45-52. doi: 10.3109/00207458808985692.
9
The autonomic nervous system and regulation of cardiovascular performance.自主神经系统与心血管功能调节
Anesthesiology. 1968 Jul-Aug;29(4):670-80. doi: 10.1097/00000542-196807000-00009.
10
Comparison of macroscopic models of excitation and force propagation in the heart.心脏中兴奋与力传播的宏观模型比较
Biomed Tech (Berl). 2002;47 Suppl 1 Pt 1:217-20. doi: 10.1515/bmte.2002.47.s1a.217.

引用本文的文献

1
A range of voltage-clamp protocol designs for rapid capture of hERG kinetics.一系列用于快速捕捉hERG动力学的电压钳协议设计。
Wellcome Open Res. 2025 Jul 9;9:673. doi: 10.12688/wellcomeopenres.23319.2. eCollection 2024.
2
Challenges and opportunities in uncertainty quantification for healthcare and biological systems.医疗保健和生物系统不确定性量化中的挑战与机遇。
Philos Trans A Math Phys Eng Sci. 2025 Mar 13;383(2292):20240232. doi: 10.1098/rsta.2024.0232.
3
Building Digital Twins for Cardiovascular Health: From Principles to Clinical Impact.构建心血管健康的数字孪生体：从原理到临床影响。
J Am Heart Assoc. 2024 Oct;13(19):e031981. doi: 10.1161/JAHA.123.031981. Epub 2024 Aug 1.
4
Uncertainty assessment of proarrhythmia predictions derived from multi-level in silico models.多水平计算模型预测致心律失常性的不确定性评估。
Arch Toxicol. 2023 Oct;97(10):2721-2740. doi: 10.1007/s00204-023-03557-6. Epub 2023 Aug 1.
5
Using UncertainSCI to Quantify Uncertainty in Cardiac Simulations.使用UncertainSCI量化心脏模拟中的不确定性。
Comput Cardiol (2010). 2020 Sep;47. doi: 10.22489/cinc.2020.275. Epub 2021 Feb 10.
6
Ion channel model reduction using manifold boundaries.基于流形边界的离子通道模型约简。
J R Soc Interface. 2022 Aug;19(193):20220193. doi: 10.1098/rsif.2022.0193. Epub 2022 Aug 10.
7
Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.用于逆弹性静力学问题以识别心肌被动材料参数和无载参考构型的稳健且高效的定点算法。
J Comput Phys. 2022 Aug;463:111266. doi: 10.1016/j.jcp.2022.111266.
8
Sensitivity analysis and inverse uncertainty quantification for the left ventricular passive mechanics.左心室被动力学的敏感性分析和反向不确定性量化。
Biomech Model Mechanobiol. 2022 Jun;21(3):953-982. doi: 10.1007/s10237-022-01571-8. Epub 2022 Apr 4.
9
Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine.包括氯喹和羟氯喹在内的抗感染化合物的心脏尖端扭转型室性心动过速风险分层建模。
R Soc Open Sci. 2021 Apr 13;8(4):210235. doi: 10.1098/rsos.210235.
10
Precision medicine in human heart modeling : Perspectives, challenges, and opportunities.精准医学在人心血管建模中的应用：观点、挑战与机遇
Biomech Model Mechanobiol. 2021 Jun;20(3):803-831. doi: 10.1007/s10237-021-01421-z. Epub 2021 Feb 12.

本文引用的文献

1
Uncertainty quantification and sensitivity analysis of left ventricular function during the full cardiac cycle.左心室功能在整个心动周期中的不确定性量化和敏感性分析。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190381. doi: 10.1098/rsta.2019.0381. Epub 2020 May 25.
2
Gaussian process manifold interpolation for probabilistic atrial activation maps and uncertain conduction velocity.基于高斯过程流形插值的概率心房激活图与不确定传导速度
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190345. doi: 10.1098/rsta.2019.0345. Epub 2020 May 25.
3
Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats.通过高斯过程仿真预测主动脉缩窄大鼠的左心室收缩功能。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190334. doi: 10.1098/rsta.2019.0334. Epub 2020 May 25.
4
An audit of uncertainty in multi-scale cardiac electrophysiology models.多尺度心脏电生理学模型不确定性的审核。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190335. doi: 10.1098/rsta.2019.0335. Epub 2020 May 25.
5
Sensitivity of a data-assimilation system for reconstructing three-dimensional cardiac electrical dynamics.三维心脏电动力学重构数据同化系统的敏感性。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190388. doi: 10.1098/rsta.2019.0388. Epub 2020 May 25.
6
Variability in electrophysiological properties and conducting obstacles controls re-entry risk in heterogeneous ischaemic tissue.电生理特性和传导障碍的变异性控制着非均质性缺血组织中的折返风险。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190341. doi: 10.1098/rsta.2019.0341. Epub 2020 May 25.
7
Personalization of electro-mechanical models of the pressure-overloaded left ventricle: fitting of Windkessel-type afterload models.压力超负荷左心室机电模型的个性化：Windkessel 型后负荷模型的拟合。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190342. doi: 10.1098/rsta.2019.0342. Epub 2020 May 25.
8
Quantification of uncertainty in a new network model of pulmonary arterial adventitial fibroblast pro-fibrotic signalling.量化肺动脉外膜成纤维细胞促纤维化信号新网络模型中的不确定性。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190338. doi: 10.1098/rsta.2019.0338. Epub 2020 May 25.
9
Considering discrepancy when calibrating a mechanistic electrophysiology model.考虑在对机制电生理学模型进行校准时的差异。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190349. doi: 10.1098/rsta.2019.0349. Epub 2020 May 25.
10
Creation and application of virtual patient cohorts of heart models.心脏模型虚拟患者队列的建立与应用。
Philos Trans A Math Phys Eng Sci. 2020 Jun 12;378(2173):20190558. doi: 10.1098/rsta.2019.0558. Epub 2020 May 25.