Swolana Denis, Kępa Małgorzata, Idzik Danuta, Dziedzic Arkadiusz, Kabała-Dzik Agata, Wąsik Tomasz J, Wojtyczka Robert D
Department of Microbiology and Virology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, ul. Jagiellońska 4, 41-200 Sosnowiec, Poland.
Department of Conservative Dentistry with Endodontics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Pl. Akademicki 17, 41-902 Bytom, Poland.
Nanomaterials (Basel). 2020 May 25;10(5):1010. doi: 10.3390/nano10051010.
Among many infectious diseases, infections caused by pathogens of species exert a substantial influence upon human health, mainly due to their continuous presence on human skin and mucous membranes. For that reason, an intensive search for new, effective anistaphyloccocal agents can currently be observed worldwide. In recent years, there has been growing interest in nanoparticles, as compounds with potential antibacterial effect. The antibacterial activity of silver containing substances has been well recognized, but thoughtful studies focused on the effect of silver nanoparticles on bacterial biofilm are scarce. The aim of this study was to assess the influence of silver nanoparticles (AgNPs) with particle sizes in the range between 10 and 100 nm, and a concentration range from 1 to 10 µg/mL, upon strains with different biofilm-forming abilities (BFAs). The studies revealed the highest level of antimicrobial activity for AgNPs in relation to strains with BFA, and what is more, the observed effect was proportional to the increasing particles' size, and strains not forming biofilm were more susceptible to silver nanoparticles with the smallest examined size, which was 10 nm.
在众多传染病中，由特定物种病原体引起的感染对人类健康产生重大影响，主要是因为它们持续存在于人体皮肤和黏膜上。因此，目前在全球范围内都能看到对新型有效抗葡萄球菌药物的深入研究。近年来，人们对纳米颗粒作为具有潜在抗菌作用的化合物越来越感兴趣。含银物质的抗菌活性已得到充分认可，但针对银纳米颗粒对细菌生物膜影响的深入研究却很少。本研究的目的是评估粒径在10至100纳米之间、浓度范围为1至10微克/毫升的银纳米颗粒（AgNPs）对具有不同生物膜形成能力（BFAs）的菌株的影响。研究表明，AgNPs对具有BFA的菌株具有最高水平的抗菌活性，而且观察到的效果与颗粒尺寸的增加成正比，未形成生物膜的菌株对所检测的最小尺寸（10纳米）的银纳米颗粒更敏感。
