酒精摄入量与血浆高密度脂蛋白胆固醇及其主要亚组分的关联：卡菲利和斯皮德韦尔心脏疾病合作研究
Associations of alcohol consumption with plasma high density lipoprotein cholesterol and its major subfractions: the Caerphilly and Speedwell Collaborative Heart Disease Studies.
作者信息
Miller N E, Bolton C H, Hayes T M, Bainton D, Yarnell J W, Baker I A, Sweetnam P M
机构信息
Department of Chemical Pathology, St. Thomas's Hospital Medical School, London.
出版信息
J Epidemiol Community Health. 1988 Sep;42(3):220-5. doi: 10.1136/jech.42.3.220.
Abstract
In surveys of 4860 middle-aged men in Caerphilly (South Wales) and Speedwell (Bristol) alcohol consumption has been related to high density lipoprotein (HDL) cholesterol and its major subfractions, HDL2 and HDL3, measured in a single fasting blood sample. The results confirm that high density lipoprotein cholesterol concentration increases as the amount of alcohol regularly consumed increases. The relationship appears to be linear and is independent of age, smoking habit, body mass index, low density lipoprotein cholesterol and plasma total triglyceride. This rise in HDL cholesterol is not mediated through either HDL2 cholesterol or HDL3 cholesterol alone. Both subclasses increase significantly and by similar amounts with increasing alcohol intake.
摘要
在对卡菲利（南威尔士）和斯皮德韦尔（布里斯托尔）的4860名中年男性进行的调查中，酒精摄入量与通过单次空腹血样测量的高密度脂蛋白（HDL）胆固醇及其主要亚组分HDL2和HDL3有关。结果证实，随着定期饮酒量的增加，高密度脂蛋白胆固醇浓度会升高。这种关系似乎是线性的，并且独立于年龄、吸烟习惯、体重指数、低密度脂蛋白胆固醇和血浆总甘油三酯。HDL胆固醇的这种升高并非仅通过HDL2胆固醇或HDL3胆固醇介导。随着酒精摄入量的增加，两个亚类均显著增加且增加量相似。
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