Andrade José Carlos, Almeida Diana, Domingos Melany, Seabra Catarina Leal, Machado Daniela, Freitas Ana Cristina, Gomes Ana Maria
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal.
CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Porto, Portugal.
Front Bioeng Biotechnol. 2020 Jun 5;8:550. doi: 10.3389/fbioe.2020.00550. eCollection 2020.
In the last years several human commensals have emerged from the gut microbiota studies as potential probiotics or therapeutic agents. Strains of human gut inhabitants such as , or have shown several interesting bioactivities and are thus currently being considered as food supplements or as live biotherapeutics, as is already the case with other human commensals such as bifidobacteria. The large-scale use of these bacteria will pose many challenges and drawbacks mainly because they are quite sensitive to oxygen and/or very difficult to cultivate. This review highlights the properties of some of the most promising human commensals bacteria and summarizes the most up-to-date knowledge on their potential health effects. A comprehensive outlook on the potential strategies currently employed and/or available to produce, stabilize, and deliver these microorganisms is also presented.
在过去几年中，几种人体共生菌已从肠道微生物群研究中脱颖而出，成为潜在的益生菌或治疗剂。人类肠道居民的菌株，如 、 或 ，已显示出多种有趣的生物活性，因此目前被视为食品补充剂或活生物治疗剂，就像双歧杆菌等其他人体共生菌的情况一样。这些细菌的大规模使用将带来许多挑战和缺点，主要是因为它们对氧气相当敏感和/或很难培养。本综述重点介绍了一些最有前途的人体共生菌的特性，并总结了关于它们潜在健康影响的最新知识。还对目前用于生产、稳定和递送这些微生物的潜在策略进行了全面展望。
