Chen Alan, Grobmyer Stephen R, Krishna Vijay B
Department of Biomedical Engineering, Lerner Research Institute and Surgical Oncology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, United States.
ACS Omega. 2020 Jun 4;5(24):14444-14450. doi: 10.1021/acsomega.0c01018. eCollection 2020 Jun 23.
Photothermal therapy, utilizing photonic nanoparticles, has gained substantial interest as an alternative to systemic cancer treatments. Several different photothermal nanoparticles have been designed and characterized for their photothermal efficiency. However, a standardized experimental methodology to determine the photothermal efficiency is lacking leading to differences in the reported values for the same nanoparticles. Here, we have determined the role of different experimental parameters on the estimation of photothermal efficiency. Importantly, we have demonstrated the role of laser irradiation time and nanoparticle concentration as the two critical factors that can lead to errors in the estimation of photothermal efficiency. Based on the optimized parameters, we determined the photothermal conversion efficiency of polyhydroxy fullerenes to be 69%. Further, the photothermal response of polyhydroxy fullerenes was found to be stable with repeated laser irradiation and no changes in the molecular structure were observed. Given its high photothermal efficiency and superior stability, polyhydroxy fullerenes are an ideal candidate for photothermal therapy.
利用光子纳米颗粒的光热疗法作为一种全身性癌症治疗的替代方法已引起广泛关注。人们设计了几种不同的光热纳米颗粒，并对其光热效率进行了表征。然而，目前缺乏一种标准化的实验方法来测定光热效率，这导致对于相同纳米颗粒所报道的值存在差异。在此，我们确定了不同实验参数在光热效率评估中的作用。重要的是，我们证明了激光照射时间和纳米颗粒浓度作为两个关键因素，可能导致光热效率评估出现误差。基于优化后的参数，我们确定多羟基富勒烯的光热转换效率为69%。此外，发现多羟基富勒烯在重复激光照射下的光热响应稳定，且未观察到分子结构发生变化。鉴于其高光热效率和卓越的稳定性，多羟基富勒烯是光热疗法的理想候选材料。
