Scott R P, Saunders D A, Norman J
University Department of Anaesthetics, Southampton General Hospital.
Anaesthesia. 1988 Jun;43(6):492-4. doi: 10.1111/j.1365-2044.1988.tb06641.x.
Eight modes of administration of propofol were assessed in order to minimise the pain of injection. An intravenous bolus injection in the antecubital fossa was the only approach that caused no pain. When administered intravenously in the dorsum of the hand the pain score and the number of patients who experienced pain was reduced significantly by mixing the agent with lignocaine when compared with a bolus injection. Slowing the speed of injection caused the greatest discomfort. An indirect biochemical mechanism for the pain is proposed.
为了尽量减少丙泊酚注射时的疼痛，对其八种给药方式进行了评估。在前臂肘窝进行静脉推注是唯一不会引起疼痛的方法。与推注相比，当将丙泊酚与利多卡因混合后经手背静脉给药时，疼痛评分和经历疼痛的患者数量显著降低。减慢注射速度会引起最大程度的不适。本文提出了疼痛的间接生化机制。
