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人类和动物通过饮食接触T-2毒素和HT-2毒素。

Human and animal dietary exposure to T-2 and HT-2 toxin.

作者信息

Arcella Davide, Gergelova Petra, Innocenti Matteo Lorenzo, Steinkellner Hans

出版信息

EFSA J. 2017 Aug 14;15(8):e04972. doi: 10.2903/j.efsa.2017.4972. eCollection 2017 Aug.

Abstract

T-2 toxin (T2) and HT-2 (HT2) toxin are trichothecenes, which form part of the group of mycotoxins. Food and feed samples used to estimate human dietary and animal exposure were reported either as the individual results for T2 and/or, HT2, and/or as the sum of the two. The highest concentrations were reported in oats and oat-containing commodities. Very high levels were reported in a small number of data on specific plant- and herb-based dietary supplements. In humans, the mean chronic dietary exposure to the sum of T2 and HT2 was highest in 'Toddlers' and 'Infants', with maximum upper bound (UB) estimates of 64.8 and 62.9 ng/kg body weight (bw) per day, respectively. The 95th percentile dietary exposure was highest in 'Infants' with a maximum UB estimate of 146 ng/kg bw per day. UB estimations were on average fourfold higher than lower bound (LB) estimations. Average acute exposure ranged from a minimum of 13.4 ng/kg bw per day, estimated in 'Elderly', up to a maximum of 64.7 ng/kg bw per day estimated in 'Toddlers'. The highest 95th percentile acute dietary exposure was estimated for a dietary survey within the age class 'Infants' (170 ng/kg bw per day). Overall, among processed foods the main contributors were cereal flakes, fine bakery wares and, for acute exposure, also bread and rolls. In the elderly and very elderly, dietary supplements made an important contribution. Exposure to the sum of T2 and HT2 in farm and companion animals varied according to the animal species. Exposures considering mean concentration scenarios varied between 0.03-0.08 (LB-UB) μg/kg bw per day in beef cattle and 1.13-1.47 μg/kg bw per day in milking goats. For high concentration scenarios, exposures varied between 0.12-0.16 μg/kg bw per day and 2.37-2.58μg/kg bw per day in the same species. In the absence of data, potential modified form were not included.

摘要

T-2毒素(T2)和HT-2毒素(HT2)属于单端孢霉烯族毒素,是霉菌毒素的一部分。用于评估人类膳食和动物接触情况的食品和饲料样本,报告的结果要么是T2和/或HT2的单独结果,要么是两者之和。燕麦和含燕麦的商品中报告的浓度最高。少数关于特定植物和草药类膳食补充剂的数据显示含量极高。在人类中,“幼儿”和“婴儿”对T2和HT2总和的慢性膳食平均接触量最高,每天的最大上限(UB)估计分别为64.8和62.9纳克/千克体重(bw)。“婴儿”的第95百分位数膳食接触量最高,最大UB估计为每天146纳克/千克bw。UB估计值平均比下限(LB)估计值高四倍。平均急性接触量范围从“老年人”估计的每天最低13.4纳克/千克bw到“幼儿”估计的每天最高64.7纳克/千克bw。“婴儿”年龄组的一项膳食调查估计,第95百分位数的最高急性膳食接触量为每天170纳克/千克bw。总体而言,在加工食品中,主要来源是谷物片、精细烘焙食品,对于急性接触来说,还有面包和小圆面包。在老年人和高龄老年人中,膳食补充剂起了重要作用。农场动物和伴侣动物对T2和HT2总和的接触因动物种类而异。考虑平均浓度情况时,肉牛的接触量在每天0.03 - 0.08(LB - UB)微克/千克bw之间,产奶山羊的接触量在每天1.13 - 1.47微克/千克bw之间。对于高浓度情况,同一物种的接触量在每天0.12 - 0.16微克/千克bw和2.37 - 2.58微克/千克bw之间。由于缺乏数据,未包括潜在的改性形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4284/7010047/88a049bf9b77/EFS2-15-e04972-g001.jpg

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