Cerny A, Zinkernagel R M, Groscurth P
Department of Experimental Pathology, Institute of Pathology, University Hospital, Zürich, Switzerland.
Cell Tissue Res. 1988 Nov;254(2):449-54. doi: 10.1007/BF00225818.
We have studied follicular dendritic cells (FDC) in lymph nodes of normal and thymus dysgeneic nude mice depleted of B-cells by chronic treatment with anti-IgM antibodies. We found that B cell depletion was accompanied by the absence of mature FDC as defined morphologically at the ultrastructural level. Only precursor FDC (p-FDC) could be demonstrated. Upon release of B-cell suppression, the repopulation of lymph nodes with B-cells was associated with the reappearance of fully differentiated FDC in primary follicles of nude mice and in secondary follicles of T-cell competent mice. We conclude that mature B-cells and/or B-cell products are required for the development of mature follicular dendritic cells in the mouse lymph node.
我们研究了通过用抗IgM抗体长期治疗而耗尽B细胞的正常和胸腺发育不全裸鼠淋巴结中的滤泡树突状细胞（FDC）。我们发现，B细胞耗竭伴随着超微结构水平上形态学定义的成熟FDC的缺失。仅能证明有前体FDC（p-FDC）。解除B细胞抑制后，裸鼠初级滤泡和T细胞功能正常小鼠的次级滤泡中B细胞在淋巴结中的重新聚集与完全分化的FDC的重新出现相关。我们得出结论，成熟的B细胞和/或B细胞产物是小鼠淋巴结中成熟滤泡树突状细胞发育所必需的。
