Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Obesity (Silver Spring). 2020 Jul;28 Suppl 1(Suppl 1):S93-S103. doi: 10.1002/oby.22799. Epub 2020 Jun 17.
Exercise has been shown to improve cardiometabolic health, yet neither the molecular connection nor the effects of exercise timing have been elucidated. The aim of this study was to investigate whether ad libitum or time-restricted mild exercise reduces atherosclerosis development in atherosclerosis-prone dyslipidemic APOE*3-Leiden.CETP mice and whether mild exercise training in men with obesity affects lipoprotein levels.
Mice were group-housed and subjected to ad libitum or time-restricted (first or last 6 hours of the active phase) voluntary wheel running for 16 weeks while on a cholesterol-rich diet, after which atherosclerosis development was assessed in the aortic root. Furthermore, nine men with obesity followed a 12-week mild exercise training program. Lipoprotein levels were measured by nuclear magnetic resonance spectroscopy in plasma collected pre and post exercise training.
Wheel running did not affect plasma lipid levels, uptake of triglyceride-derived fatty acids by tissues, and aortic atherosclerotic lesion size or severity. Markers of training status were unaltered. Exercise training in men with obesity did not alter lipoprotein levels.
Mild exercise training does not reduce dyslipidemia or atherosclerosis development in APOE*3-Leiden.CETP mice or affect lipoprotein levels in humans. Future research on the effects of (time-restricted) exercise on atherosclerosis or lipid metabolism should consider more vigorous exercise protocols.
运动已被证明可以改善心脏代谢健康，但运动的分子联系及其时机的影响仍未阐明。本研究旨在探讨随意或限时轻度运动是否能减少易患动脉粥样硬化的血脂异常 APOE*3-Leiden.CETP 小鼠的动脉粥样硬化发展，以及肥胖男性进行轻度运动训练是否会影响脂蛋白水平。
将小鼠分组饲养，并在富含胆固醇的饮食下进行随意或限时（活动期的前或后 6 小时）自愿轮跑 16 周，然后评估主动脉根部的动脉粥样硬化发展情况。此外，9 名肥胖男性参加了为期 12 周的轻度运动训练计划。运动训练前后通过磁共振波谱法测量血浆中的脂蛋白水平。
轮跑运动不会影响血浆脂质水平、组织对甘油三酯衍生脂肪酸的摄取以及主动脉粥样硬化病变的大小或严重程度。训练状态标志物没有改变。肥胖男性的运动训练并没有改变脂蛋白水平。
轻度运动训练不能减少 APOE*3-Leiden.CETP 小鼠的血脂异常或动脉粥样硬化发展，也不能影响人类的脂蛋白水平。未来关于（限时）运动对动脉粥样硬化或脂质代谢影响的研究应考虑更剧烈的运动方案。
