天然产物和复合成分激活免疫系统：癌症治疗中的网络药理学方法
Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment.
作者信息
Gomez-Cadena Alejandra, Barreto Alfonso, Fioretino Susana, Jandus Camilla
机构信息
Department of Pathology and Immunology, Targeting of Cytokine Secreting Lymphocyte group, Geneva University, Geneva, Switzerland.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland.
出版信息
Cell Stress. 2020 May 18;4(7):154-166. doi: 10.15698/cst2020.07.224.
Abstract
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments. However, a promising field in the current therapies based on plant-derived compounds is the study of their immunomodulation properties and their capacity to activate the immune system to fight against multifactorial diseases like cancer. In this review we discuss how network pharmacology could help to characterize and validate natural single molecules or more complex preparations as promising cancer therapies based on their multitarget capacities.
摘要
天然产物和传统草药是替代生物活性化合物的重要来源，但很少有植物制剂经过科学评估和验证其作为医学治疗手段的潜力。然而，在目前基于植物衍生化合物的疗法中，一个有前景的领域是研究它们的免疫调节特性以及激活免疫系统对抗诸如癌症等多因素疾病的能力。在这篇综述中，我们讨论网络药理学如何有助于基于其多靶点能力，将天然单一分子或更复杂的制剂表征和验证为有前景的癌症疗法。
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