Kupersmith M J, Burde R M, Warren F A, Klingele T G, Frohman L P, Mitnick H
Department of Neurology, New York University Medical Center, New York.
J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1381-6. doi: 10.1136/jnnp.51.11.1381.
Fourteen patients, 12 of whom were women, with an age range from 26 to 56 years, presented with progressive or recurrent optic neuropathy, despite conventional doses of corticosteroid, and laboratory evidence of collagen vascular disease. The visual loss was severe and most had an acuity less than 20/200. Megadose corticosteroid therapy improved the vision in 11 of the 12 patients. Continued oral prednisone and cytotoxic drugs were necessary to maintain vision in nine patients. Patients with autoimmune optic neuropathy must be differentiated from cases with idiopathic optic neuritis or multiple sclerosis to facilitate the appropriate therapy.
14名患者，其中12名女性，年龄在26至56岁之间，尽管接受了常规剂量的皮质类固醇治疗，但仍出现进行性或复发性视神经病变，并有胶原血管病的实验室证据。视力丧失严重，大多数患者视力低于20/200。大剂量皮质类固醇治疗使12名患者中的11名视力得到改善。9名患者需要持续口服泼尼松和细胞毒性药物以维持视力。自身免疫性视神经病变患者必须与特发性视神经炎或多发性硬化症患者相鉴别，以便进行适当的治疗。
