Lin Hui-Ching, Sheu Shi-Yuan, Sheen Lee-Yan, Sheu Pei-Wen, Chiang Wenchang, Kuo Tzong-Fu
Institute of Food Science and Technology, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan, ROC.
School of Medicine, Chung Shan Medical University, No.110, Sec.1, Jianguo N. Rd., Taichung, 40201, Taiwan, ROC.
J Tradit Complement Med. 2020 Jan 17;10(4):336-344. doi: 10.1016/j.jtcme.2020.01.003. eCollection 2020 Jul.
Foxtail millet ( (L.) P. Beauv.) and adlay ( L. var. Stapf.) seeds have substantial benefits possesses remarkable edible and nutritive values, and ease of processing and food manufacturing. They have nutraceutical properties in the form of antioxidants which prevent deterioration of human health and have long been used in traditional Chinese medicine as a remedy for many diseases. The present study is designed to investigate the gastroprotective effect of foxtail millet and adlay processing product (APP) diet on water immersion restraint stress (WIRS) induced ulceration in rats. We examined the effects of intake of AIN-93G diet containing either foxtail millet (10, 20 and 40%, 4 weeks) or APP (15 and 30%, 5 weeks) on macroscopic ulcer index (UI), plasma calcium level, lipid peroxidation products (estimated by the thiobarbituric acid reactive substances; TBARS), non-protein sulfhydryl (NPSH), digestive enzyme activities, and histopathology were determined. The results showed that pretreatment with millet and adlay diets significantly prevented the gastric mucosal lesion development. In addition, ulcerated rats showed depletion of NPSH levels whereas treatment with millet and adlay reverted this decline in stress-induced rats. Histological studies confirmed the results. The finding suggests that millet and adlay diets promote ulcer protection by the decrease in ulcer index, TBARS values and increase NPSH concentrations. Millet and adlay diets retain the advantage of being a natural product which may protect the gastric mucosa against ulceration.
谷子（(L.) P. Beauv.）和薏苡（L. var. Stapf.）种子具有诸多益处，拥有显著的食用和营养价值，且易于加工及食品制造。它们具有抗氧化剂形式的营养保健特性，可预防人类健康恶化，长期以来在传统中医中被用作多种疾病的治疗药物。本研究旨在探讨谷子和薏苡加工产品（APP）饮食对水浸束缚应激（WIRS）诱导的大鼠溃疡的胃保护作用。我们检测了摄入含谷子（10%、20%和40%，4周）或APP（15%和30%，5周）的AIN-93G饮食对宏观溃疡指数（UI）、血浆钙水平、脂质过氧化产物（通过硫代巴比妥酸反应性物质；TBARS评估）、非蛋白巯基（NPSH）、消化酶活性的影响，并确定了组织病理学情况。结果表明，用谷子和薏苡饮食预处理可显著预防胃黏膜损伤的发展。此外，溃疡大鼠的NPSH水平降低，而用谷子和薏苡处理可逆转应激诱导大鼠的这种下降。组织学研究证实了这些结果。该发现表明，谷子和薏苡饮食通过降低溃疡指数、TBARS值和增加NPSH浓度来促进溃疡保护。谷子和薏苡饮食保留了作为天然产物的优势，可能保护胃黏膜免受溃疡侵害。
