Khatami Alireza, Pormohammad Ali, Farzi Rana, Saadati Hassan, Mehrabi Maryam, Kiani Seyed Jalal, Ghorbani Saied
Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Department of Biological Sciences, University of Calgary, Calgary, AB Canada.
Infect Agent Cancer. 2020 Jul 22;15:48. doi: 10.1186/s13027-020-00314-7. eCollection 2020.
Breast cancer is reported as one of the most common cancers among females worldwide. Infectious agents especially viruses have been considered as role players in the development of breast cancer. Although some investigations suggest an association between bovine leukemia virus (BLV) and breast cancer, the involvement of this virus as a risk factor remains controversial. The present study aimed to find out any possible association between BLV and breast cancer through conducting a systematic review and meta-analysis.
Systematic literature search was performed by finding related case-control articles from the PubMed, Google Scholar, Web of Science, Scopus, and EMBASE databases. The heterogeneity and the multivariable-adjusted OR and corresponding 95% CI were applied by meta-analysis and forest plot across studies. All statistical analyses were performed using Stata 14.1.
Based on a comprehensive literature search, 9 case-control studies were included for meta-analysis. The combination of all included studies showed that BLV infection is associated with an increased risk of breast cancer [summary OR (95% CI) 2.57 (1.45, 4.56)].
This is the first meta-analysis to analyze a potential association between BLV infection and the risk of breast cancer. Control of the infection in cattle herds and screening of the milk and dairy products may help to reduce the transmission of the virus to humans.
乳腺癌是全球女性中最常见的癌症之一。感染因子尤其是病毒被认为在乳腺癌的发生发展中起作用。尽管一些研究表明牛白血病病毒（BLV）与乳腺癌之间存在关联，但该病毒作为危险因素的作用仍存在争议。本研究旨在通过系统评价和荟萃分析，找出BLV与乳腺癌之间的任何可能关联。
通过在PubMed、谷歌学术、科学网、Scopus和EMBASE数据库中查找相关病例对照文章进行系统的文献检索。通过荟萃分析和森林图对各研究的异质性以及多变量调整后的OR值和相应的95%置信区间进行分析。所有统计分析均使用Stata 14.1进行。
基于全面的文献检索，纳入9项病例对照研究进行荟萃分析。所有纳入研究的综合结果显示，BLV感染与乳腺癌风险增加相关[汇总OR（95%置信区间）2.57（1.45，4.56）]。
这是第一项分析BLV感染与乳腺癌风险之间潜在关联的荟萃分析。控制牛群中的感染以及对牛奶和乳制品进行筛查可能有助于减少病毒向人类的传播。
