Physiology Section, Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, University of Barcelona (UB), 08028 Barcelona, Spain.
Nutrition and Food Safety Research Institute (INSA-UB), 08921 Santa Coloma de Gramenet, Spain.
Nutrients. 2020 Jul 23;12(8):2196. doi: 10.3390/nu12082196.
The study's objective was to ascertain whether a nutritional multivitamin and mineral supplement enriched with two different dietary fibers influences microbiota composition, mineral absorption, and some immune and metabolic biomarkers in adult rats. Nine-week-old Wistar rats were randomly assigned into four groups: the reference group; the group receiving a daily supplement based on a food matrix with proteins, vitamins, and minerals; and two other groups receiving this supplement enriched with inulin (V + I) or acacia (V + A) fiber for four weeks. Microbiota composition was determined in cecal content and mineral content in fecal, blood, and femur samples. Intestinal IgA concentration, hematological, and biochemical variables were evaluated. Both V + I and V + A supplementations increased and phyla, which were associated with a higher presence of and spp. V + A supplementation increased calcium, magnesium, phosphorus, and zinc concentrations in femur. V + I supplementation increased the fecal IgA content and reduced plasma total cholesterol and uric acid concentration. Both fiber-enriched supplements tested herein seem to be beneficial to gut-health, although differently.
本研究旨在确定富含两种不同膳食纤维的营养复合维生素和矿物质补充剂是否会影响成年大鼠的微生物群落组成、矿物质吸收以及一些免疫和代谢生物标志物。9 周龄 Wistar 大鼠被随机分为四组：对照组；接受基于蛋白质、维生素和矿物质的食物基质的每日补充剂的组；以及另外两组接受这种补充剂，其中含有菊糖（V+I）或阿拉伯胶（V+A）纤维，为期四周。在盲肠内容物和粪便、血液和股骨样本中确定微生物群落组成。评估肠道 IgA 浓度、血液学和生化变量。V+I 和 V+A 补充均增加了 和 门，这与 和 spp 的更高存在有关。V+A 补充增加了股骨中的钙、镁、磷和锌浓度。V+I 补充增加了粪便 IgA 含量，并降低了血浆总胆固醇和尿酸浓度。本文测试的两种纤维强化补充剂似乎都有益于肠道健康，但作用方式不同。
