Department of Medicine, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Health Science Center, Tulane University, New Orleans, Louisiana, USA.
Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA.
Obesity (Silver Spring). 2020 Oct;28(10):1798-1801. doi: 10.1002/oby.22937. Epub 2020 Aug 4.
Coronavirus disease 2019 (COVID-19) has disproportionately impacted the African American community. This study aims to identify the risk factors for severe COVID-19 disease in African American patients.
This was a retrospective cross-sectional analysis of African American patients with COVID-19 treated between March 12 and April 9, 2020, at a single tertiary center. The primary outcome of interest was severe disease defined as those requiring intensive care unit (ICU) admission.
The study included 158 consecutive patients. The mean age was 57 years, and 61% were women. The mean (SD) of BMI was 33.2 (8.6) kg/m . Overall, patients admitted to the ICU were older (62 vs. 55 years, P = 0.003) and had higher BMI (36.5 kg/m vs. 31.9 kg/m , P = 0.002). In unadjusted and adjusted analysis, the factors most associated with ICU admission in this sample were age (adjusted odds ratio [aOR]: 1.073; 95% CI: 1.033-1.114), BMI (aOR: 1.115; 95% CI: 1.052-1.182), and lung disease (aOR: 3.097; 95% CI: 1.137-8.437).
This study identified risk factors for severe disease in COVID-19, specifically in an African American population. Further inclusive research aimed at optimizing clinical care relevant to the African American population is critical to ensure an equitable response to COVID-19.
2019 年冠状病毒病（COVID-19）对非裔美国人社区的影响不成比例。本研究旨在确定非裔美国 COVID-19 患者发生严重 COVID-19 疾病的危险因素。
这是对 2020 年 3 月 12 日至 4 月 9 日期间在一家三级中心接受治疗的非裔美国 COVID-19 患者进行的回顾性横断面分析。主要观察指标为重症疾病，定义为需要入住重症监护病房（ICU）的患者。
本研究纳入了 158 例连续患者。患者的平均年龄为 57 岁，61%为女性。BMI 的平均值（标准差）为 33.2（8.6）kg/m²。总体而言，入住 ICU 的患者年龄较大（62 岁 vs. 55 岁，P=0.003），BMI 较高（36.5 kg/m² vs. 31.9 kg/m²，P=0.002）。在未调整和调整分析中，该样本中与 ICU 入院最相关的因素是年龄（调整后的优势比[OR]：1.073；95%置信区间[CI]：1.033-1.114）、BMI（调整后的 OR：1.115；95% CI：1.052-1.182）和肺部疾病（调整后的 OR：3.097；95% CI：1.137-8.437）。
本研究确定了 COVID-19 严重疾病的危险因素，特别是在非裔美国人人群中。进一步开展旨在优化与非裔美国人相关的临床护理的包容性研究，对于确保对 COVID-19 的公平应对至关重要。
