Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Chair for Biomarkers of Chronic Diseases, Riyadh Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Nutrients. 2020 Aug 10;12(8):2395. doi: 10.3390/nu12082395.
An abnormal lipid profile is an independent risk factor for cardiovascular diseases. The relationship between vitamin B12 deficiency and lipid profile is inconclusive, with most studies conducted in unhealthy populations. In this study, we aimed to assess the relationship between serum vitamin B12 levels and lipid profiles in a cross-sectional study that included 341 apparently healthy Saudi women, aged 19-30 years, from different colleges at King Saud University, Saudi Arabia. Sociodemographic, anthropometric, biochemical, and lifestyle data were collected, including diet and physical activity. Serum vitamin B12 deficiency was defined as serum B12 level of <148 pmol/L. The prevalence of vitamin B12 deficiency was approximately 0.6%. Using multivariable linear regression models, serum vitamin B12 levels were found to be inversely associated with total cholesterol (B = -0.26; < 0.001), low-density lipoprotein cholesterol levels (B = -0.30; < 0.001), and triglyceride (B = -0.16; < 0.01) after adjusting for potential confounders, while obesity indices of body mass index, central obesity, and fat percentage showed no association. Therefore, we conclude that low serum vitamin B12 levels are independently associated with abnormal lipid profiles in healthy young Saudi women. Further interventional studies are needed to determine whether improving serum vitamin B12 levels in a healthy population can improve lipid profiles.
异常的脂质谱是心血管疾病的独立危险因素。维生素 B12 缺乏与脂质谱之间的关系尚无定论，大多数研究都是在不健康的人群中进行的。在这项研究中，我们旨在评估血清维生素 B12 水平与来自沙特阿拉伯沙特国王大学不同学院的 341 名年龄在 19-30 岁之间的健康沙特女性横断面研究中的脂质谱之间的关系。收集了社会人口统计学、人体测量学、生物化学和生活方式数据，包括饮食和体育活动。血清维生素 B12 缺乏症的定义为血清 B12 水平<148 pmol/L。维生素 B12 缺乏症的患病率约为 0.6%。使用多变量线性回归模型，在调整了潜在混杂因素后，血清维生素 B12 水平与总胆固醇（B = -0.26；<0.001）、低密度脂蛋白胆固醇水平（B = -0.30；<0.001）和甘油三酯（B = -0.16；<0.01）呈负相关，而体重指数、中心性肥胖和脂肪百分比等肥胖指数则没有关联。因此，我们得出结论，低血清维生素 B12 水平与健康年轻沙特女性的异常脂质谱独立相关。需要进一步的干预研究来确定在健康人群中提高血清维生素 B12 水平是否可以改善脂质谱。
