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Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture.

作者信息

Rath N C, Oronsky A L, Kerwar S S

机构信息

Department of Inflammation and Immunology, American Cyanamid Company, Lederle Laboratories Division, Pearl River, New York 10965.

出版信息

Clin Immunol Immunopathol. 1988 Apr;47(1):39-46. doi: 10.1016/0090-1229(88)90143-2.

DOI:10.1016/0090-1229(88)90143-2
PMID:3280189
Abstract

Chondrocytes prepared from the articular cartilage of young rats synthesize and secrete an interleukin-1-like activity into the medium. The physical and biochemical properties of this IL-1-like activity are similar to macrophage-derived IL-1. Immunological studies suggest that this activity is related to IL-1 alpha. Isolated chondrocytes and those grown in culture can express Ia.

摘要

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