Youssef Fadia S, Mamatkhanova Munira A, Mamadalieva Nilufar Z, Zengin Gokhan, Aripova Salima F, Alshammari Elham, Ashour Mohamed L
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
Institute of the Chemistry of Plant Substances, Academy of Sciences of RUz, Mirzo Ulugbek str. 77, Tashkent 100170, Uzbekistan.
Antibiotics (Basel). 2020 Aug 14;9(8):518. doi: 10.3390/antibiotics9080518.
The differences in the composition of essential oils obtained from the aerial parts of six species viz., (), (), (), (), () and () were detected both qualitatively and semi-quantitatively using GC-MS and GC-FID analyses. One hundred and six metabolites were identified that account for 92.1, 96.43, 87.43, 95.95, 92.90 and 89.48% of , , , , and whole essential oils, respectively. The data from the GC-MS analyses were subjected to unsupervised pattern recognition chemometric analysis utilizing principal component analysis (PCA) to improve the visualization of such differences among the six species. and are very closely related to each other and were gathered together in one cluster. The antioxidant potential was assessed in vitro using different assays including 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), ferric reducing power (FRAP) and phosphomolybdenum (PM) assays. and exhibited the most notable antioxidant properties as evidenced by their pronounced activities in most of the antioxidant assays performed, followed by . showed the most effective tyrosinase inhibitory potential, which was estimated as 119.67 mgKAE/g oil, while exhibited the most potent α-amylase inhibitory potential, which was equivalent to 2.61 mmol ACAE/g oil. Thus, it was concluded that species could serve as a promising natural antioxidant drug that could be included in different products and spices to alleviate hyperglycemia and used as a natural ingredient in pharmaceutical cosmetics to counteract hyperpigmentation.
使用气相色谱 - 质谱联用（GC - MS）和气相色谱 - 氢火焰离子化检测器（GC - FID）分析，对六种植物地上部分所提取精油的成分差异进行了定性和半定量检测。共鉴定出106种代谢产物，分别占[六种植物名称未给出]整个精油的92.1%、96.43%、87.43%、95.95%、92.90%和89.48%。利用主成分分析（PCA）对GC - MS分析数据进行无监督模式识别化学计量分析，以更好地呈现这六种植物之间的差异。[两种植物名称未给出]彼此密切相关，聚为一类。通过不同的体外实验评估抗氧化潜力，包括2,2'-联氮 - 双（3 - 乙基苯并噻唑啉 - 6 - 磺酸）（ABTS）、铜离子还原抗氧化能力（CUPRAC）、铁离子还原能力（FRAP）和磷钼酸（PM）实验。[几种植物名称未给出]在大多数抗氧化实验中表现出显著活性，展现出最显著的抗氧化特性，其次是[一种植物名称未给出]。[一种植物名称未给出]显示出最有效的酪氨酸酶抑制潜力，估计为119.67 mgKAE/g油，而[一种植物名称未给出]表现出最有效的α - 淀粉酶抑制潜力，相当于2.61 mmol ACAE/g油。因此，得出结论，[植物名称未给出]物种可作为一种有前景的天然抗氧化药物，可纳入不同产品和香料中以缓解高血糖，并用作药用化妆品中的天然成分以对抗色素沉着。
