Barfidokht Abbas, Mishra Rupesh K, Seenivasan Rajesh, Liu Shuyang, Hubble Lee J, Wang Joseph, Hall Drew A
Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA.
Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Sens Actuators B Chem. 2019 Oct 1;296. doi: 10.1016/j.snb.2019.04.053. Epub 2019 Apr 14.
Rapid, on-site detection of fentanyl is of critical importance, as it is an extremely potent synthetic opioid that is prone to abuse. Here we describe a wearable glove-based sensor that can detect fentanyl electrochemically on the fingertips towards decentralized testing for opioids. The glove-based sensor consists of flexible screen-printed carbon electrodes modified with a mixture of multiwalled carbon nanotubes and a room temperature ionic liquid, 4-(3-butyl-1-imidazolio)-1-butanesulfonate). The sensor shows direct oxidation of fentanyl in both liquid and powder forms with a detection limit of 10 μM using square-wave voltammetry. The "Lab-on-a-Glove" sensors, combined with a portable electrochemical analyzer, provide wireless transmission of the measured data to a smartphone or tablet for further analysis. The integrated sampling and sensing methodology on the thumb and index fingers, respectively, enables rapid screening of fentanyl in the presence of a mixture of cutting agents and offers considerable promise for timely point-of-need screening for first responders. Such a glove-based "swipe, scan, sense, and alert" strategy brings chemical analytics directly to the user's fingertips and opens new possibilities for detecting substances of abuse in emergency situations.
快速现场检测芬太尼至关重要，因为它是一种极易滥用的强效合成阿片类药物。在此，我们描述了一种基于可穿戴手套的传感器，该传感器能够在指尖上以电化学方式检测芬太尼，用于阿片类药物的分散检测。基于手套的传感器由用多壁碳纳米管和室温离子液体4-(3-丁基-1-咪唑鎓)-1-丁烷磺酸盐的混合物修饰的柔性丝网印刷碳电极组成。该传感器使用方波伏安法对液体和粉末形式的芬太尼均显示出直接氧化，检测限为10 μM。“手套实验室”传感器与便携式电化学分析仪相结合，可将测量数据无线传输到智能手机或平板电脑进行进一步分析。分别在拇指和食指上的集成采样和传感方法能够在存在切割剂混合物的情况下快速筛查芬太尼，并为急救人员及时进行即时需求筛查提供了巨大希望。这种基于手套的“擦拭、扫描、传感和警报”策略将化学分析直接带到用户的指尖，并为在紧急情况下检测滥用物质开辟了新的可能性。
