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全球黑人生存问题至关重要:重新调整精准肿瘤学,以实现癌症护理的真正公平。

Black Lives Matter Worldwide: Retooling Precision Oncology for True Equity of Cancer Care.

机构信息

Section of Hematology/Oncology, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA.

Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL 60637, USA.

出版信息

Cell Rep Med. 2020 Aug 25;1(5):100079. doi: 10.1016/j.xcrm.2020.100079.

DOI:10.1016/j.xcrm.2020.100079
PMID:32864637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7446667/
Abstract

In a recent issue of , Carrot-Zhang et al. identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA). Their study findings and limitations highlight the critical need to diversify populations represented in cancer genomics research.

摘要

在最近的一期 中,Carrot-Zhang 等人在癌症基因组图谱 (TCGA) 的患者中鉴定了具有特定祖先的分子变异和表达变化。他们的研究发现和局限性强调了在癌症基因组学研究中使人群多样化的迫切需要。

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本文引用的文献

1
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.癌症遗传祖源的综合分析及其分子相关性
Cancer Cell. 2020 May 11;37(5):639-654.e6. doi: 10.1016/j.ccell.2020.04.012.
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Pan-cancer analysis of whole genomes.泛癌症全基因组分析。
Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5.
3
Assembly of a pan-genome from deep sequencing of 910 humans of African descent.从非洲裔 910 人的深度测序中组装泛基因组。
Nat Genet. 2019 Jan;51(1):30-35. doi: 10.1038/s41588-018-0273-y. Epub 2018 Nov 19.
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Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features.尼日利亚乳腺癌的特征分析揭示了普遍存在的同源重组缺陷和侵袭性分子特征。
Nat Commun. 2018 Oct 16;9(1):4181. doi: 10.1038/s41467-018-06616-0.
5
Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers.跨癌种的遗传祖源与基因组改变的综合分析。
Cancer Cell. 2018 Oct 8;34(4):549-560.e9. doi: 10.1016/j.ccell.2018.08.019.
6
DNA methylation markers for diagnosis and prognosis of common cancers.用于常见癌症诊断和预后的 DNA 甲基化标志物。
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7414-7419. doi: 10.1073/pnas.1703577114. Epub 2017 Jun 26.
7
Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.《癌症基因组图谱》中非洲裔和欧洲裔人群乳腺癌分子特征与生存的比较。
JAMA Oncol. 2017 Dec 1;3(12):1654-1662. doi: 10.1001/jamaoncol.2017.0595.
8
Cancer statistics for African Americans, 2016: Progress and opportunities in reducing racial disparities.2016 年非裔美国人癌症统计数据:减少种族差异方面的进展和机会。
CA Cancer J Clin. 2016 Jul;66(4):290-308. doi: 10.3322/caac.21340. Epub 2016 Feb 22.
9
Triple-negative breast cancer in African-American women: disparities versus biology.非裔美国女性的三阴性乳腺癌:差异与生物学特性
Nat Rev Cancer. 2015 Apr;15(4):248-54. doi: 10.1038/nrc3896. Epub 2015 Feb 12.
10
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.微小RNA作为环境暴露或效应的潜在标志物:一项系统综述
Environ Health Perspect. 2015 May;123(5):399-411. doi: 10.1289/ehp.1408459. Epub 2015 Jan 16.