Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Mar Drugs. 2020 Aug 27;18(9):450. doi: 10.3390/md18090450.
The actinomycete strain LY001 was purified from the sponge . Fractionation of the antimicrobial extract of the culture of the actinomycete afforded three new natural chlorinated derivatives of 3-phenylpropanoic acid, 3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid (), 3-(3,5-dichloro-4-hydroxyphenyl)propanoic acid methyl ester (), and 3-(3-chloro-4-hydroxyphenyl)propanoic acid (), together with 3-phenylpropanoic acid (), -cinnamic acid (), and the diketopiperazine alkaloids cyclo(l-Phe--4-OH-l-Pro) () and cyclo(l-Phe--4-OH-d-Pro) () were isolated. Interpretation of nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS) data of - supported their assignments. Compounds - are first candidates of the natural chlorinated phenylpropanoic acid derivatives. The production of the chlorinated derivatives of 3-phenylpropionic acid (-) by provides insight into the biosynthetic capabilities of the marine-derived actinomycetes. Compounds - demonstrated significant and selective activities towards and , while displayed more sensitivity towards compounds and , suggesting a selectivity effect of these compounds against .
从海绵中分离到放线菌菌株 LY001。从放线菌培养物的抗菌提取物中分离得到三种新的天然氯化 3-苯丙酸衍生物，3-(3,5-二氯-4-羟基苯基)丙酸（）、3-(3,5-二氯-4-羟基苯基)丙酸甲酯（）和 3-(3-氯-4-羟基苯基)丙酸（），以及 3-苯丙酸（）、-肉桂酸（）和二酮哌嗪生物碱环（l-Phe-l-4-OH-l-Pro）（）和环（l-Phe-l-4-OH-d-Pro）（）。核磁共振（NMR）和高分辨率电喷雾电离质谱（HRESIMS）数据的解释支持了它们的分配。化合物-是天然氯化苯丙酸衍生物的首批候选物。海洋来源放线菌产生的 3-苯丙酸氯化衍生物（-）为其生物合成能力提供了深入了解。化合物-对和具有显著和选择性的活性，而对化合物和更敏感，表明这些化合物对具有选择性作用。
