Master's and Doctor's Degree Program in Industrial Biotecnology at Universidade Positivo, Curitiba, Paraná, Brazil.
Master's and Doctor's Degree Program in Industrial Biotecnology at Universidade Positivo, Curitiba, Paraná, Brazil.
J Ethnopharmacol. 2021 Jan 30;265:113300. doi: 10.1016/j.jep.2020.113300. Epub 2020 Aug 29.
Cordia verbenacea DC is a plant whose geographical distribution is all over Brazil, but mainly on the country's coastal areas. It is used by folk medicine to treat inflammations and chronic pain with application of the raw extract of macerated leaves in the region of pain. This paper aims to provide an integrative review of the role of chemical compounds present in the extract and the essential oil of Cordia verbenacea DC for their anti-inflammatory, antimicrobial and healing properties. The extract of Cordia verbenacea DC is widely found within popular culture as teas, decoctions, infusions, pomades/creams for anti-inflammatory, antimicrobial and healing uses. Its extract is mainly composed of α-humulene, α-pinene, trans-caryophyllene, artemetin, spathulenol and allo-aromadrendene. The described effects of the chemical compounds found in the extract are applied to muscle bruising and myofascial pain, edema reduction and chronic tendonitis, when used topically (with a comercial product being marketed); and to rheumatic, neuralgic and arthritic processes, when used orally as an anti-ulcerative agent; as well as for its healing and analgesic properties when used topically or as infusion according to test results using animals. Besides its use in chronic pain and topical application, in vitro studies have revealed the importance of antimicrobial action by inhibiting the bacterial growth of the components present in the Cordia verbenacea DC extract. In addition to expanding knowledge about Cordia verbenacea, other studies are being developed with the extract and essential oil in order to expand knowledge about healing aspects of topical use. Although other studies are being conducted, the results presented in this analysis provide a rich database of the activities found in the compounds found in the extract and the essential oil, in addition to promoting knowledge of the best extraction method cited. Therefore, such studies constitute a preliminary source of information to encourage new pieces of research, species conservation, safe management of the species, use of the extract/essential oil and development of plant-based products.
黄槐决明 DC 是一种植物，其地理分布遍布巴西，但主要集中在该国沿海地区。民间医学用其生提取物涂抹于疼痛部位来治疗炎症和慢性疼痛。本文旨在综合综述黄槐决明 DC 提取物和精油中所含化合物的抗炎、抗菌和愈合特性的作用。黄槐决明 DC 的提取物在民间文化中广泛用作茶、煎剂、浸剂、用于抗炎、抗菌和愈合用途的油膏/乳膏。其提取物主要由 α-葎草烯、α-蒎烯、反式石竹烯、莪术醇、斯巴醇和别-芳樟醇组成。所描述的提取物中发现的化合物的作用应用于肌肉瘀伤和肌筋膜疼痛、减少肿胀和慢性肌腱炎，当局部使用（有一种商业化产品上市）；以及风湿、神经痛和关节炎过程，当口服作为抗溃疡剂；以及其愈合和镇痛作用，当局部或根据使用动物的试验结果作为输液使用。除了在慢性疼痛和局部应用中的用途外，体外研究还揭示了通过抑制黄槐决明 DC 提取物中存在的成分的细菌生长来发挥抗菌作用的重要性。除了扩展对黄槐决明的了解外，还正在进行其他关于提取物和精油的研究，以扩展关于局部使用愈合方面的知识。尽管正在进行其他研究，但本分析中提供的结果为提取物和精油中发现的化合物的活性提供了丰富的数据库，此外还促进了对引用的最佳提取方法的了解。因此，这些研究构成了鼓励新的研究、物种保护、物种安全管理、提取物/精油的使用以及植物性产品开发的初步信息来源。
