Heinsberg Lacey W, Bui Christina N N, Hartle Jennifer C, Sereika Susan M, Choy Courtney C, Wang Dongqing, Soti-Ulberg Christina, Naseri Take, Reupena Muagututia Sefuiva, Duckham Rachel L, Park Jennifer J, Hawley Nicola L, Deziel Nicole C
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT 06510, USA.
Toxics. 2020 Sep 2;8(3):67. doi: 10.3390/toxics8030067.
The Pacific Island nation of Samoa is marked by prevalent obesity and an increasing dependence on packaged foods likely to contain the endocrine disruptor bisphenol-A (BPA). We evaluated participant- and household-level characteristics associated with estimated dietary BPA exposure in Samoan mothers and their children and examined associations between dietary BPA exposure and body mass index (BMI) and abdominal circumference (AC). Dietary BPA exposure indices were estimated for 399 mother-child pairs by combining information from dietary questionnaires and relative concentrations of BPA measured in foods/beverages. We observed moderate to strong correlation between mother-child daily BPA indices (Spearman's rho = 0.7, < 0.0001). In mothers, we observed lower daily BPA indices in those who were less physically active ( = 0.0004) and living in homes with higher income ( = 0.00001). In children, we observed lower daily BPA indices in those living in homes with higher income ( = 0.0003) and following a less modern dietary pattern ( = 0.002), and higher daily BPA indices in those who were less physically active ( = 0.02). No significant associations were observed between daily BPA indices and BMI or AC. Despite this, the application of the daily BPA index identified factors associated with dietary BPA exposure and warrants further examination in Samoa and other understudied populations.
太平洋岛国萨摩亚存在普遍肥胖问题，且对可能含有内分泌干扰物双酚A（BPA）的包装食品的依赖日益增加。我们评估了与萨摩亚母亲及其子女膳食BPA估计暴露量相关的参与者和家庭层面特征，并研究了膳食BPA暴露量与体重指数（BMI）和腹围（AC）之间的关联。通过结合膳食问卷信息和食品/饮料中测量的BPA相对浓度，对399对母婴的膳食BPA暴露指数进行了估计。我们观察到母婴每日BPA指数之间存在中度至强相关性（斯皮尔曼相关系数rho = 0.7，<0.0001）。在母亲中，我们观察到身体活动较少的母亲（= 0.0004）和收入较高家庭的母亲（= 0.00001）每日BPA指数较低。在儿童中，我们观察到收入较高家庭的儿童（= 0.0003）和遵循较不现代饮食模式的儿童（= 0.002）每日BPA指数较低，而身体活动较少的儿童（= 0.02）每日BPA指数较高。未观察到每日BPA指数与BMI或AC之间存在显著关联。尽管如此，每日BPA指数的应用确定了与膳食BPA暴露相关的因素，值得在萨摩亚和其他研究不足的人群中进一步研究。
