Kenya Medical Research Institute, Center for Global Health Research, Kisumu, Kenya.
Kenya Medical Research Institute, Center for Global Health Research, Kisumu, Kenya.
Vaccine. 2020 Oct 7;38(43):6832-6838. doi: 10.1016/j.vaccine.2020.08.015. Epub 2020 Sep 4.
Influenza vaccination during pregnancy benefits mothers and children. Kenya and other low- and middle-income countries have no official influenza vaccination policies to date but are moving towards issuing such policies. Understanding determinants of influenza vaccine uptake during pregnancy in these settings is important to inform policy decisions and vaccination rollout.
We interviewed a convenience sample of women at antenatal care facilities in four counties (Nairobi, Mombasa, Marsabit, Siaya) in Kenya. We described knowledge and attitudes regarding influenza vaccination and assessed factors associated with willingness to receive influenza vaccine.
We enrolled 507 pregnant women, median age was 26 years (range 15-43). Almost half (n = 240) had primary or no education. Overall, 369 (72.8%) women had heard of influenza. Among those, 288 (78.1%) believed that a pregnant woman would be protected if vaccinated, 252 (68.3%) thought it was safe to receive a vaccine while pregnant, and 223 (60.4%) believed a baby would be protected if mother was vaccinated. If given opportunity, 309 (83.7%) pregnant women were willing to receive the vaccine. Factors associated with willingness to receive influenza vaccine were mothers' belief in protective effect (OR 3.87; 95% CI 1.56, 9.59) and safety (OR 5.32; 95% CI 2.35, 12.01) of influenza vaccines during pregnancy.
Approximately one third of pregnant women interviewed had never heard of influenza. Willingness to receive influenza vaccine was high among women who had heard about influenza. If the Kenyan government recommends influenza vaccine for pregnant women, mitigation of safety concerns and education on the benefits of vaccination could be the most effective strategies to improve vaccine acceptance.
孕妇接种流感疫苗对母亲和儿童均有益处。肯尼亚和其他中低收入国家目前尚未制定官方的流感疫苗接种政策，但正在朝着这一方向努力。了解这些国家孕妇对流感疫苗接种的接受程度的决定因素，对于为政策决策和疫苗推广提供信息非常重要。
我们采访了肯尼亚四个县（内罗毕、蒙巴萨、马萨比特、锡亚）的产前保健机构的方便样本中的妇女。我们描述了她们对流感疫苗接种的知识和态度，并评估了与接种意愿相关的因素。
我们共招募了 507 名孕妇，中位年龄为 26 岁（范围 15-43 岁）。近一半（n=240）的孕妇仅接受过小学或以下教育。总体而言，369 名（72.8%）女性听说过流感。其中，288 名（78.1%）女性认为孕妇接种疫苗后会得到保护，252 名（68.3%）认为孕妇接种疫苗是安全的，223 名（60.4%）认为如果母亲接种疫苗，婴儿将得到保护。如果有机会，309 名（83.7%）孕妇愿意接种疫苗。与接种流感疫苗意愿相关的因素是母亲对流感疫苗在怀孕期间的保护作用（OR 3.87；95%CI 1.56，9.59）和安全性（OR 5.32；95%CI 2.35，12.01）的信任。
约三分之一接受采访的孕妇从未听说过流感。对流感有一定了解的孕妇对接种流感疫苗的意愿较高。如果肯尼亚政府建议孕妇接种流感疫苗，减轻对安全性的担忧，并对疫苗接种的益处进行教育，可能是提高疫苗接种接受度的最有效策略。
