Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia QLD 4116, Australia.
Centre for Cell Factories and Biopolymers, Griffith Institute for Drug Discovery, Griffith University, Nathan QLD 4111, Australia.
Colloids Surf B Biointerfaces. 2020 Sep;193:111108. doi: 10.1016/j.colsurfb.2020.111108. Epub 2020 May 5.
Biomineralization of metal organic frameworks (MOFs) using biomolecules has recently attracted significant interest because of the benign process including room temperature, neutral pH and without the requirement of any other chemical reagents. Also, these biomolecule incorporated MOFs (biomolecules@MOFs) have demonstrated their potential in biomolecule encapsulation, protection and controlled release. This work aims to develop a general strategy to make biomolecules@MOFs via a biomimetic mineralization process. A library of biomolecules (peptides and proteins) with different charges were systematically studied to fundamentally understand the role of biomolecules and their proprieties in biomolecule-mediated MOF biomineralization. Biomolecule charge, amino acid sequence and stirring speed have been demonstrated to play important roles in controlling biomineralization reaction rate, particle shape and morphology.
金属有机骨架（MOFs）的生物矿化作用最近引起了人们的极大兴趣，因为其过程温和，包括室温、中性 pH 值，且无需任何其他化学试剂。此外，这些包含生物分子的 MOFs（biomolecules@MOFs）已在生物分子封装、保护和控制释放方面展示出了潜力。本工作旨在开发一种通过仿生矿化过程制备生物分子@MOFs 的通用策略。我们系统地研究了具有不同电荷的生物分子（肽和蛋白质）文库，以从根本上理解生物分子的作用及其特性在生物分子介导的 MOF 生物矿化中的作用。生物分子的电荷、氨基酸序列和搅拌速度已被证明在控制生物矿化反应速率、颗粒形状和形态方面起着重要作用。
