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茶树中 MAPK 级联基因家族：计算机鉴定、表达谱分析及调控网络分析。

MAPK cascade gene family in Camellia sinensis: In-silico identification, expression profiles and regulatory network analysis.

机构信息

Department of Life Sciences, Garden City University, Bangalore, Karnataka, India.

National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi, India.

出版信息

BMC Genomics. 2020 Sep 7;21(1):613. doi: 10.1186/s12864-020-07030-x.

DOI:10.1186/s12864-020-07030-x
PMID:32894062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7487466/
Abstract

BACKGROUND

Mitogen Activated Protein Kinase (MAPK) cascade is a fundamental pathway in organisms for signal transduction. Though it is well characterized in various plants, there is no systematic study of this cascade in tea.

RESULT

In this study, 5 genes of Mitogen Activated Protein Kinase Kinase (MKK) and 16 genes of Mitogen Activated Protein Kinase (MPK) in Camellia sinensis were found through a genome-wide search taking Arabidopsis thaliana as the reference genome. Also, phylogenetic relationships along with structural analysis which includes gene structure, location as well as protein conserved motifs and domains, were systematically examined and further, predictions were validated by the results. The plant species taken for comparative study clearly displayed segmental duplication, which was a significant candidate for MAPK cascade expansion. Also, functional interaction was carried out in C. sinensis based on the orthologous genes in Arabidopsis. The expression profiles linked to various stress treatments revealed wide involvement of MAPK and MAPKK genes from Tea in response to various abiotic factors. In addition, the expression of these genes was analysed in various tissues.

CONCLUSION

This study provides the targets for further comprehensive identification, functional study, and also contributed for a better understanding of the MAPK cascade regulatory network in C. sinensis.

摘要

背景

丝裂原活化蛋白激酶（MAPK）级联是生物信号转导的基本途径。尽管它在各种植物中都得到了很好的描述，但在茶中还没有对该级联进行系统研究。

结果

本研究通过以拟南芥为参考基因组的全基因组搜索，在茶树中发现了 5 个丝裂原活化蛋白激酶激酶（MKK）基因和 16 个丝裂原活化蛋白激酶（MPK）基因。此外，还对系统发育关系以及结构分析（包括基因结构、位置以及蛋白质保守基序和结构域）进行了全面检查，并根据结果进行了进一步的预测验证。用于比较研究的植物物种明显显示出片段重复，这是 MAPK 级联扩张的重要候选者。此外，还基于拟南芥中的同源基因在茶树中进行了功能相互作用。与各种胁迫处理相关的表达谱表明，MAPK 和 MAPKK 基因广泛参与了茶树对各种非生物因素的反应。此外，还分析了这些基因在各种组织中的表达。

结论

本研究为进一步的全面鉴定、功能研究提供了目标，并有助于更好地理解茶树中 MAPK 级联调控网络。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/5653729d58c7/12864_2020_7030_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/35ae26929911/12864_2020_7030_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/3048929e92d4/12864_2020_7030_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/44366a5c428f/12864_2020_7030_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/a14fcfb36b3b/12864_2020_7030_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/a1d8c1a2a322/12864_2020_7030_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/bbd208578a0d/12864_2020_7030_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/3dd1a334d384/12864_2020_7030_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/0380fab1b42f/12864_2020_7030_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/5653729d58c7/12864_2020_7030_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/35ae26929911/12864_2020_7030_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/3048929e92d4/12864_2020_7030_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/44366a5c428f/12864_2020_7030_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/a14fcfb36b3b/12864_2020_7030_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/a1d8c1a2a322/12864_2020_7030_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/bbd208578a0d/12864_2020_7030_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/3dd1a334d384/12864_2020_7030_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/0380fab1b42f/12864_2020_7030_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2086/7487466/5653729d58c7/12864_2020_7030_Fig9_HTML.jpg

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