Institute of Research in Infectious Diseases (IRIM), Centre National de la Recherche Scientifique (CNRS), UMR9004, University of Montpellier, Team R2D2, 34293 Montpellier, France.
Viruses. 2020 Sep 4;12(9):982. doi: 10.3390/v12090982.
HIV-1 is the causative agent of acquired immunodeficiency syndrome (AIDS). It affects millions of people worldwide and the pandemic persists despite the implementation of highly active antiretroviral therapy. A wide spectrum of techniques has been implemented in order to diagnose and monitor AIDS progression over the years. Besides the conventional approaches, microfluidics has provided useful methods for monitoring HIV-1 infection. In this review, we introduce continuous microfluidics as well as the fabrication and handling of microfluidic chips. We provide a review of the different applications of continuous microfluidics in AIDS diagnosis and progression and in the basic study of the HIV-1 life cycle.
HIV-1 是获得性免疫缺陷综合征（AIDS）的病原体。它影响着全球数百万人，尽管实施了高效抗逆转录病毒疗法，但这种大流行仍在持续。多年来，已经实施了广泛的技术来诊断和监测 AIDS 的进展。除了传统方法之外，微流控技术还为监测 HIV-1 感染提供了有用的方法。在这篇综述中，我们介绍了连续微流控技术以及微流控芯片的制造和处理。我们回顾了连续微流控技术在 AIDS 诊断和进展以及 HIV-1 生命周期基础研究中的不同应用。
