Niculet Elena, Radaschin Diana Sabina, Nastase Florentina, Draganescu Miruna, Baroiu Liliana, Miulescu Magdalena, Arbune Manuela, Tatu Alin Laurentiu
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University, 800010 Galati, Romania.
Department of Pathology, 'Sf. Apostol Andrei' Emergency Clinical Hospital, 800578 Galati, Romania.
Exp Ther Med. 2020 Oct;20(4):3421-3424. doi: 10.3892/etm.2020.9013. Epub 2020 Jul 14.
Cytokines involved in pathogenesis of psoriasis such as interleukins (IL-1β, IL-6, IL-17, IL-22, IL-23), interferon-α, tumor necrosis factor-α and interferon-γ can also become therapeutic targets. Research currently uses murine models of imiquimod-induced psoriatic-type dermatitis in order to analyze potentially helpful phytotherapeutics for psoriasis treatment: , , , , , , , , , and various Chinese herbal formulas. Psoriasis is a chronic inflammatory disease with complex pathogenic mechanisms that yield abnormal immune responses with clinical and morphological echoes (erythematous, scaly plaques with a histopathological basis made up of alterations i.e. keratinocyte aberrant proliferation, parakeratosis or chronic inflammation). The current therapeutic approach has only been able to manage the disease, without ensuring a certified treatment, thus giving rise to the need for better medications. This novel therapeutic approach has shown promising results in preclinical studies, giving hope for future phytochemical animal-based studies.
参与银屑病发病机制的细胞因子，如白细胞介素（IL-1β、IL-6、IL-17、IL-22、IL-23）、干扰素-α、肿瘤坏死因子-α和干扰素-γ，也可成为治疗靶点。目前的研究使用咪喹莫特诱导的银屑病样皮炎小鼠模型，以分析对银屑病治疗可能有帮助的植物疗法： ， ， ， ， ， ， ， ， 以及各种中药配方。银屑病是一种慢性炎症性疾病，其致病机制复杂，会产生异常免疫反应，并伴有临床和形态学表现（红斑、鳞屑性斑块，组织病理学基础包括角质形成细胞异常增殖、角化不全或慢性炎症等改变）。目前的治疗方法只能控制病情，无法确保根治，因此需要更好的药物。这种新的治疗方法在临床前研究中已显示出有希望的结果，为未来基于植物化学物质的动物研究带来了希望。
