Luong John H T, Narayan Tarun, Solanki Shipra, Malhotra Bansi D
School of Chemistry and the Analytical and Biological Chemistry Research Facility (ABCRF), University College Cork, College Road, Cork T12 YN60, Ireland.
Department of Biotechnology, Delhi Technological University, Delhi 110042, India.
J Funct Biomater. 2020 Sep 25;11(4):71. doi: 10.3390/jfb11040071.
Conducting polymers (CPs) have been at the center of research owing to their metal-like electrochemical properties and polymer-like dispersion nature. CPs and their composites serve as ideal functional materials for diversified biomedical applications like drug delivery, tissue engineering, and diagnostics. There have also been numerous biosensing platforms based on polyaniline (PANI), polypyrrole (PPY), polythiophene (PTP), and their composites. Based on their unique properties and extensive use in biosensing matrices, updated information on novel CPs and their role is appealing. This review focuses on the properties and performance of biosensing matrices based on CPs reported in the last three years. The salient features of CPs like PANI, PPY, PTP, and their composites with nanoparticles, carbon materials, etc. are outlined along with respective examples. A description of mediator conjugated biosensor designs and enzymeless CPs based glucose sensing has also been included. The future research trends with required improvements to improve the analytical performance of CP-biosensing devices have also been addressed.
导电聚合物（CPs）因其类似金属的电化学性质和类似聚合物的分散特性而一直处于研究的中心。CPs及其复合材料是用于药物递送、组织工程和诊断等多种生物医学应用的理想功能材料。也有许多基于聚苯胺（PANI）、聚吡咯（PPY）、聚噻吩（PTP）及其复合材料的生物传感平台。基于其独特的性质以及在生物传感基质中的广泛应用，有关新型CPs及其作用的最新信息很有吸引力。本综述重点关注过去三年报道的基于CPs的生物传感基质的性质和性能。概述了PANI、PPY、PTP等CPs及其与纳米颗粒、碳材料等复合材料的显著特征，并给出了相应示例。还介绍了介体共轭生物传感器设计以及基于无酶CPs的葡萄糖传感。同时也探讨了未来的研究趋势以及为提高CP生物传感装置的分析性能所需的改进。
