4-喹诺酮类药物对大肠杆菌中R质粒转移的抑制作用。
Inhibition of R-plasmid transfer in Escherichia coli by 4-quinolones.
作者信息
Weisser J, Wiedemann B
出版信息
Antimicrob Agents Chemother. 1987 Apr;31(4):531-4. doi: 10.1128/AAC.31.4.531.
Abstract
Inhibition of transfer of four conjugative R plasmids by ciprofloxacin, enoxacin, norfloxacin, ofloxacin, and pipemidic acid was investigated in an Escherichia coli mating system. The absolute concentrations needed for inhibition of conjugation varied from 0.12 microgram/ml for ciprofloxacin to 16 micrograms/ml for pipemidic acid, but the relationship to the MICs for the parent strains was identical for all substrates. Concentrations for a 90% reduction of transconjugants were in the range of one to six times the MIC for the parent strains, which also had lethal effects on donors and recipients. A similar effect on conjugation was found with chloramphenicol. These observations question the specificity of transfer inhibition by quinolones and cast doubt on the clinical importance of such an effect.
摘要
在大肠杆菌交配系统中研究了环丙沙星、依诺沙星、诺氟沙星、氧氟沙星和吡哌酸对四种接合性R质粒转移的抑制作用。抑制接合所需的绝对浓度从环丙沙星的0.12微克/毫升到吡哌酸的16微克/毫升不等，但所有底物与亲本菌株的最低抑菌浓度（MIC）的关系是相同的。使转接合子减少90%的浓度范围是亲本菌株MIC的1至6倍，这对供体菌和受体菌也有致死作用。氯霉素对接合也有类似作用。这些观察结果对喹诺酮类药物转移抑制的特异性提出了质疑，并对这种作用的临床重要性产生怀疑。
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