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用于骨组织工程的细胞支架

Cell Scaffolds for Bone Tissue Engineering.

作者信息

Iijima Kazutoshi, Otsuka Hidenori

机构信息

Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan.

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

出版信息

Bioengineering (Basel). 2020 Sep 30;7(4):119. doi: 10.3390/bioengineering7040119.

DOI:10.3390/bioengineering7040119
PMID:33007995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7711861/
Abstract

Currently, well-known surgical procedures for bone defects are classified into four types: (1) autogenous bone graft transplantation, (2) allogeneic bone graft transplantation, (3) xenogeneic bone graft transplantation, and (4) artificial bone graft transplantation. However, they are often risky procedures and related to postoperative complications. As an alternative, tissue engineering to regenerate new bone often involves the use of mesenchymal stem cells (MSCs), derived from bone marrow, adipose tissues, and so on, which are cultured into three-dimensional (3D) scaffolds to regenerate bone tissue by osteoinductive signaling. In this manuscript, we provide an overview of recent treatment of bone defects and the studies on the creation of cell scaffolds for bone regeneration. Bone regeneration from bone marrow-derived mesenchymal stem cells using silica nonwoven fabric by the authors' group were provided. Potential application and future direction of the present systems were also described.

摘要

目前，治疗骨缺损的知名外科手术方法分为四类：（1）自体骨移植，（2）同种异体骨移植，（3）异种骨移植，以及（4）人工骨移植。然而，这些手术往往风险较大，且与术后并发症相关。作为一种替代方法，用于再生新骨的组织工程通常涉及使用源自骨髓、脂肪组织等的间充质干细胞（MSC），这些细胞被培养到三维（3D）支架中，通过骨诱导信号来再生骨组织。在本手稿中，我们概述了近期骨缺损的治疗方法以及用于骨再生的细胞支架的研究。作者团队利用二氧化硅无纺布从骨髓间充质干细胞再生骨的情况也作了介绍。还描述了本系统的潜在应用和未来方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/7e67db656cf2/bioengineering-07-00119-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/fc751d42d1ee/bioengineering-07-00119-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/28df54fec23c/bioengineering-07-00119-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/dd7e7120d7d6/bioengineering-07-00119-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/2dfc8f22b0e7/bioengineering-07-00119-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/ab941bdf1563/bioengineering-07-00119-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/7e67db656cf2/bioengineering-07-00119-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/fc751d42d1ee/bioengineering-07-00119-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/28df54fec23c/bioengineering-07-00119-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/dd7e7120d7d6/bioengineering-07-00119-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/2dfc8f22b0e7/bioengineering-07-00119-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/ab941bdf1563/bioengineering-07-00119-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98e2/7711861/7e67db656cf2/bioengineering-07-00119-g006.jpg

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