Mantziari Anastasia, Salminen Seppo, Szajewska Hania, Malagón-Rojas Jeadran Nevardo
Functional Foods Forum, Faculty of Medicine, University of Turku, 20520 Turku, Finland.
Department of Paediatrics at the Medical University of Warsaw, 02091 Warsaw, Poland.
Microorganisms. 2020 Sep 30;8(10):1510. doi: 10.3390/microorganisms8101510.
The Sustainable Development goals for 2020 included reducing all causes associated with infant and perinatal mortality in their priorities. The use of compounds with bioactive properties has been proposed as a therapeutic strategy due to their stimulating effect on the host's immune system. Additionally, biotherapeutic products such as postbiotics, tentatively defined as compounds produced during a fermentation process that support health and well-being, promote intestinal barrier integrity without posing considerable risks to children's health. Although this is a concept in development, there are increasing studies in the field of nutrition, chemistry, and health that aim to understand how postbiotics can help prevent different types of infections in priority populations such as minors under the age of five. The present review aims to describe the main mechanisms of action of postbiotics. In addition, it presents the available current evidence regarding the effects of postbiotics against pathogens commonly involved in pediatric infections. Postbiotics may constitute a safe alternative capable of modulating the cellular response and stimulating the host's humoral response.
2020年可持续发展目标将降低与婴儿和围产期死亡率相关的所有原因列为优先事项。由于具有生物活性的化合物对宿主免疫系统有刺激作用，因此已提出将其用作治疗策略。此外，生物治疗产品，如暂定定义为在发酵过程中产生的支持健康和福祉的化合物的后生元，可促进肠道屏障完整性，且不会对儿童健康构成重大风险。尽管这是一个尚在发展中的概念，但营养、化学和健康领域的研究越来越多，旨在了解后生元如何帮助预防五岁以下未成年人等优先人群中的不同类型感染。本综述旨在描述后生元的主要作用机制。此外，它还介绍了目前关于后生元对儿科感染中常见病原体影响的现有证据。后生元可能构成一种安全的替代方案，能够调节细胞反应并刺激宿主的体液反应。
