Nocera Francesca Paola, Mancini Simone, Najar Basma, Bertelloni Fabrizio, Pistelli Luisa, De Filippis Anna, Fiorito Filomena, De Martino Luisa, Fratini Filippo
Department of Veterinary Medicine and Animal Production, Via Delpino 1, University of Naples "Federico II", 80137 Naples, Italy.
Department of Veterinary Sciences, Viale delle Piagge 2, University of Pisa, 56124 Pisa, Italy.
Animals (Basel). 2020 Oct 1;10(10):1782. doi: 10.3390/ani10101782.
This study aimed to test the antimicrobial activity of 11 essential oils (EOs) against four methicillin-resistant (MRSP) and four methicillin-susceptible (MSSP) clinical isolates. The obtained findings demonstrated a clear efficacy of some tested EOs against both MRSP and MSSP strains. Particularly, modal minimum inhibitory concentration (MIC) values ranging from 1:2048 / for against an MSSP strain to 1:256 / for against all MRSP strains were observed. The best results, highlighting a modal MIC value of 1:1024 / for all tested isolates, was provided by . Intriguingly, showed, in many cases, a correspondence between minimum bactericidal concentration (MBC) and MIC values, indicating that the inhibiting dose is also often bactericidal. Moreover, a mild antibacterial and bactericidal activity against both MRSP and MSSP isolates was detected for the other tested EOs. Considering the zoonotic potential of and the increased dissemination of multidrug-resistant strains, the employment of EOs could be useful for the treatment of canine pyoderma. Since antibiotic resistance has become the most urgent issue, from the perspective of the One Health initiative, alternative therapeutic approaches are desirable to limit the use of antibiotics or to improve the efficacy of conventional therapies.
本研究旨在测试11种精油（EOs）对4株耐甲氧西林（MRSP）和4株甲氧西林敏感（MSSP）临床分离株的抗菌活性。所得结果表明，一些受试精油对MRSP和MSSP菌株均有明显疗效。特别是，观察到模态最小抑菌浓度（MIC）值范围从针对一株MSSP菌株的1:2048到针对所有MRSP菌株的1:256。 提供了最佳结果，突出显示所有受试分离株的模态MIC值为1:1024。有趣的是， 在许多情况下，最小杀菌浓度（MBC）和MIC值之间存在对应关系，表明抑制剂量通常也是杀菌的。此外，还检测到其他受试精油对MRSP和MSSP分离株具有轻度抗菌和杀菌活性。考虑到 的人畜共患病潜力以及多重耐药菌株传播的增加，精油的使用可能有助于治疗犬脓皮病。由于抗生素耐药性已成为最紧迫的问题，从“同一个健康”倡议的角度来看，需要替代治疗方法来限制抗生素的使用或提高传统疗法的疗效。
