Équipe de Médecine Evolutive Faculté de chirurgie dentaire; UMR5288; CNRS/Université Paul-Sabiater Toulouse III, Toulouse, 31400, France.
Lyon Neuroscience Research Center, CNRS UMR5292, INSERM U1028, University Claude Bernard Lyon 1, Bron, France.
Nat Commun. 2020 Oct 14;11(1):5152. doi: 10.1038/s41467-020-18963-y.
In response to the COVID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive care units. Accurate metrics of disease spread are critical for the reopening strategies. Here, we show that self-reports of smell/taste changes are more closely associated with hospital overload and are earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators. We also report a decrease in self-reports of new onset smell/taste changes as early as 5 days after lockdown enforcement. Cross-country comparisons demonstrate that countries that adopted the most stringent lockdown measures had faster declines in new reports of smell/taste changes following lockdown than a country that adopted less stringent lockdown measures. We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as an indicator of COVID-19 spread in the population.
针对 COVID-19 大流行,许多政府采取了严厉措施以避免重症监护病房人满为患。准确的疾病传播指标对于重新开放策略至关重要。在这里,我们表明,自我报告的嗅觉/味觉变化与医院超负荷更密切相关,并且是 SARS-CoV-2 感染传播的早期标志物,比当前政府指标更早。我们还报告说,封锁实施后最早 5 天,自我报告的新发嗅觉/味觉变化就有所减少。跨国比较表明,采取最严格封锁措施的国家在封锁后报告新发嗅觉/味觉变化的下降速度快于采取较不严格封锁措施的国家。我们提出,一般人群中突然出现嗅觉和味觉变化的发生率增加可能可作为人群中 COVID-19 传播的指标。