Department of Infectious Diseases, Odense University Hospital, Odense, Denmark; OPEN, Open Patient data Explorative Network, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
Int J Infect Dis. 2021 Jan;102:212-219. doi: 10.1016/j.ijid.2020.10.018. Epub 2020 Oct 12.
We aimed to describe clinical characteristics and outcomes of admitted COVID-19 patients in a Danish hospital setting where an early active government intervention was taken.
Prospective cohort study including all admitted patients to the COVID-19 unit at Odense University Hospital from March 10 to April 21, 2020. Patients were assessed by a multidisciplinary team at admission. Outcome parameters were development of acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, death and admission time.
We included 83 patients (median age 62 years, 62.7% male). At hospitalization, 31.3% needed oxygen supplementation and the median National Early Warning Score was four. Median admission time was 7 days (Interquartile ranges (IQR) 3-12). In total, ARDS was diagnosed in 33.7% (28/83) of the patients corresponding to an incidence rate of 7.1 per 100 person days (95% CI: 4.1-10.2). Overall 13 patients (15.7%) were transferred to the ICU of whom 11 (84.6%) received corticosteroids.. No patients died while admitted to the ICU. Four patients (4.8%) died during admission.
Despite similar patient characteristics compared to those reported by others, we found a low overall mortality of < 5%.
我们旨在描述丹麦一家医院中收治的 COVID-19 患者的临床特征和结局，该医院采取了早期积极的政府干预措施。
前瞻性队列研究，纳入 2020 年 3 月 10 日至 4 月 21 日期间入住奥胡斯大学医院 COVID-19 病房的所有患者。患者在入院时由多学科团队进行评估。结局参数包括急性呼吸窘迫综合征（ARDS）的发展、入住重症监护病房（ICU）、死亡和入院时间。
我们共纳入 83 例患者（中位年龄 62 岁，62.7%为男性）。住院时，31.3%的患者需要吸氧，中位国家早期预警评分（National Early Warning Score，NEWS）为 4 分。中位入院时间为 7 天（四分位间距（Interquartile ranges，IQR）为 3-12 天）。共有 33.7%（28/83）的患者诊断为 ARDS，发病率为 7.1/100 人日（95%置信区间：4.1-10.2）。共有 13 例（15.7%）患者转至 ICU，其中 11 例（84.6%）接受了皮质类固醇治疗。无 ICU 住院患者死亡。4 例（4.8%）患者在住院期间死亡。
尽管患者特征与其他报告相似，但我们发现总体死亡率<5%，较低。
