Department of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Department of Obstetrics and Gynecology, University Hospital Aachen (UKA), 52074 Aachen, Germany.
Cells. 2020 Oct 21;9(10):2334. doi: 10.3390/cells9102334.
Molecular imaging plays an increasingly important role in the diagnosis and treatment of different malignancies. Radiolabeled probes enable the visualization of the primary tumor as well as the metastases and have been also employed in targeted therapy and theranostic approaches. With breast cancer being the most common malignancy in women worldwide it is of special interest to develop novel targeted treatments. However, tumor microenvironment and escape mechanisms often limit their therapeutic potential. Addressing tumor stroma associated targets provides a promising option to inhibit tumor growth and angiogenesis and to disrupt tumor tissue architecture. This review describes recent developments on radiolabeled probes used in diagnosis and treatment of breast cancer especially in triple negative type with the focus on potential targets offered by the tumor microenvironment, like tumor associated macrophages, cancer associated fibroblasts, and endothelial cells.
分子成像在不同恶性肿瘤的诊断和治疗中发挥着越来越重要的作用。放射性标记探针能够可视化原发性肿瘤以及转移灶，并且已经被应用于靶向治疗和诊断与治疗一体化方法中。由于乳腺癌是全世界女性中最常见的恶性肿瘤，因此开发新的靶向治疗方法具有特殊意义。然而，肿瘤微环境和逃逸机制常常限制了它们的治疗潜力。针对肿瘤基质相关靶点为抑制肿瘤生长和血管生成以及破坏肿瘤组织结构提供了一个很有前途的选择。本综述描述了用于诊断和治疗乳腺癌的放射性标记探针的最新进展，特别是在三阴性乳腺癌中，重点介绍了肿瘤微环境提供的潜在靶点，如肿瘤相关巨噬细胞、癌相关成纤维细胞和内皮细胞。
