Parra-Cantu Carolina, Li Wanlu, Quiñones-Hinojosa Alfredo, Zhang Yu Shrike
Division of Engineering in Medicine, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Department of Neurosurgery, Oncology, Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
J 3D Print Med. 2020 Jun;4(2):113-125. doi: 10.2217/3dp-2019-0027. Epub 2020 Oct 28.
The most common and malignant primary brain tumor in adults is glioblastoma (GBM). 3D brain models are needed to better understand the pathological processes underlying GBM and ultimately develop more efficient antineoplastic agents. Here, we describe the bioprinting methods that have been used to fabricate volumetric GBM models. We explain several factors that should be considered for 3D bioprinting, including bioinks, cells and construct designs, in relation to GBM modeling. Although 3D-bioprinted brain models are still to be improved, they have the potential to become a powerful tool for drug screening.
成人群体中最常见且具恶性的原发性脑肿瘤是胶质母细胞瘤（GBM）。需要3D脑模型来更好地理解GBM背后的病理过程，并最终开发出更有效的抗肿瘤药物。在此，我们描述了用于构建立体GBM模型的生物打印方法。我们解释了在GBM建模中3D生物打印应考虑的几个因素，包括生物墨水、细胞和构建设计。尽管3D生物打印的脑模型仍有待改进，但它们有潜力成为药物筛选的有力工具。
