Löwa Norbert, Gutkelch Dirk, Welge Ernst-Albrecht, Welz Roland, Meier Florian, Baki Abdulkader, Bleul Regina, Klein Thorsten, Wiekhorst Frank
Physikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany.
Postnova Analytics GmbH, Max-Planck-Straße 14, 86899 Landsberg am Lech, Germany.
Nanomaterials (Basel). 2020 Nov 17;10(11):2277. doi: 10.3390/nano10112277.
Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes.
磁性纳米颗粒具有独特的磁性，可用于各种生物医学治疗和诊断应用。这些应用对纳米颗粒的磁性有很高的要求。因此，磁性纳米颗粒的研究、开发和质量保证需要强大的分析方法，能够检测相关的结构参数，尤其是磁性参数。通过将纳米颗粒合成与磁性探测器直接耦合，可以获得和评估相关的纳米颗粒特性，并实时调整制造过程。本文介绍了一种灵敏且快速的磁性探测器，用于在磁性纳米颗粒连续微混合器合成过程中对其进行在线表征。该探测器基于对暴露于25 kHz振荡激发下的磁性纳米颗粒的非线性动态磁响应的测量，这一技术也称为磁颗粒光谱学。我们的结果强调了所开发的磁性在线检测与基于微混合器方法的磁性纳米颗粒合成耦合的极佳适用性。该探测器在过程监测方面已证实的实用性和可靠性为进一步的应用领域奠定了基础，例如作为色谱分离过程的监测工具。
