嗜神经病毒感染的分子发病机制
Molecular pathogenesis of neurotropic viral infections.
作者信息
Gonzalez-Scarano F, Tyler K L
机构信息
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
出版信息
Ann Neurol. 1987 Nov;22(5):565-74. doi: 10.1002/ana.410220502.
Abstract
Classical virologists defined a number of viruses that affect the nervous system and identified tissue tropism, extraneural replication, and viremia as important parameters that determine whether viral infections will affect the central nervous system. Molecular techniques are expanding this knowledge by permitting us to relate specific genes and gene products to two defined phenotypes: neuroinvasion and neurovirulence. Two converging situations make this knowledge particularly useful: (1) the development of antiviral drugs and subunit vaccines, which mandate that pathogenesis be related to specific regions of the viral genome; and (2) the expanding problem of central nervous system infections in immunodeficient states.
摘要
传统病毒学家定义了多种影响神经系统的病毒，并确定了组织嗜性、神经外复制和病毒血症是决定病毒感染是否会影响中枢神经系统的重要参数。分子技术通过使我们能够将特定基因和基因产物与两种明确的表型（神经侵袭和神经毒力）联系起来，正在扩展这方面的知识。两种相互交织的情况使得这些知识尤为有用：（1）抗病毒药物和亚单位疫苗的研发，这要求发病机制与病毒基因组的特定区域相关；（2）免疫缺陷状态下中枢神经系统感染问题的不断扩大。
相似文献
1
Molecular pathogenesis of neurotropic viral infections.嗜神经病毒感染的分子发病机制
Ann Neurol. 1987 Nov;22(5):565-74. doi: 10.1002/ana.410220502.
2
Molecular and genetic aspects of the pathogenesis of viral infections of the central nervous system.中枢神经系统病毒感染发病机制的分子和遗传学方面
Crit Rev Neurobiol. 1987;3(3):221-43.
3
The use of molecular techniques in studying viral pathogenesis in the nervous system.
Trends Neurosci. 1990 Oct;13(10):424-31. doi: 10.1016/0166-2236(90)90125-t.
4
[Neurotropic influenza type A viruses].[嗜神经A型流感病毒]
Vopr Virusol. 1984 Mar-Apr;29(2):210-3.
5
Molecular studies of viral pathogenesis in the central nervous system. The Linacre Lecture 1991.中枢神经系统病毒发病机制的分子研究。1991年林纳克讲座
J R Coll Physicians Lond. 1992 Apr;26(2):204-14.
6
Enterovirus A71 Induces Neurological Diseases and Dynamic Variants in Oral Infection of Human SCARB2-Transgenic Weaned Mice.肠道病毒A71在人SCARB2转基因断奶小鼠口腔感染中诱发神经疾病及动态变体。
J Virol. 2021 Oct 13;95(21):e0089721. doi: 10.1128/JVI.00897-21. Epub 2021 Aug 11.
7
Analysis of the molecular basis of neuropathogenesis of RNA viruses in experimental animals: relevance for human disease?实验动物中RNA病毒神经发病机制的分子基础分析：与人类疾病的相关性？
Neuropathol Appl Neurobiol. 1994 Apr;20(2):91-102. doi: 10.1111/j.1365-2990.1994.tb01167.x.
8
Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection.神经亲和性肠道病毒的再现：为感染而共占细胞途径。
Viruses. 2021 Jan 22;13(2):166. doi: 10.3390/v13020166.
9
Role of oxidative damage in the pathogenesis of viral infections of the nervous system.氧化损伤在神经系统病毒感染发病机制中的作用。
Histol Histopathol. 2005 Jul;20(3):957-67. doi: 10.14670/HH-20.957.
10
Host receptors: the key to establishing cells with broad viral tropism for vaccine production.宿主受体：为生产疫苗而建立具有广泛病毒嗜性的细胞的关键。
Crit Rev Microbiol. 2020 Mar;46(2):147-168. doi: 10.1080/1040841X.2020.1735992. Epub 2020 Mar 23.
引用本文的文献
1
Neurological disorders of COVID-19: insights to applications of natural products from plants and microorganisms.COVID-19 引发的神经系统疾病：植物和微生物天然产物应用的新见解。
Arch Pharm Res. 2022 Dec;45(12):909-937. doi: 10.1007/s12272-022-01420-3. Epub 2022 Nov 28.
2
Nervous System Manifestations of Arboviral Infections.虫媒病毒感染的神经系统表现
Curr Trop Med Rep. 2022;9(4):107-118. doi: 10.1007/s40475-022-00262-9. Epub 2022 Sep 15.
3
Neurological Complications of COVID-19: Underlying Mechanisms and Management.新型冠状病毒肺炎相关神经系统并发症：发病机制与治疗。
Int J Mol Sci. 2021 Apr 15;22(8):4081. doi: 10.3390/ijms22084081.
4
Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System.解析严重急性呼吸综合征冠状病毒2（SARS-CoV-2）侵入中枢神经系统的可能途径
Curr Treat Options Neurol. 2020;22(11):37. doi: 10.1007/s11940-020-00647-z. Epub 2020 Sep 25.
5
Severe acute respiratory syndrome coronavirus 2 may be an underappreciated pathogen of the central nervous system.严重急性呼吸综合征冠状病毒 2 可能是中枢神经系统中被低估的病原体。
Eur J Neurol. 2020 Nov;27(11):2348-2360. doi: 10.1111/ene.14442. Epub 2020 Aug 14.
6
Neurologic Alterations Due to Respiratory Virus Infections.呼吸道病毒感染所致的神经功能改变
Front Cell Neurosci. 2018 Oct 26;12:386. doi: 10.3389/fncel.2018.00386. eCollection 2018.
7
Can antiglycolipid antibodies present in HIV-infected individuals induce immune demyelination?感染HIV的个体中存在的抗糖脂抗体能引发免疫性脱髓鞘吗？
Neuropathology. 2000 Dec;20(4):257-72. doi: 10.1046/j.1440-1789.2000.00356.x.
8
A single nucleotide change in the 5' noncoding region of Sindbis virus confers neurovirulence in rats.辛德毕斯病毒5'非编码区的单核苷酸变化赋予大鼠神经毒性。
J Virol. 1999 Dec;73(12):10440-6. doi: 10.1128/JVI.73.12.10440-10446.1999.
9
Genetic determinants of Sindbis virus neuroinvasiveness.辛德毕斯病毒神经侵袭性的遗传决定因素。
J Virol. 1997 Apr;71(4):2636-46. doi: 10.1128/JVI.71.4.2636-2646.1997.
10
Loss of active neuroinvasiveness in attenuated strains of West Nile virus: pathogenicity in immunocompetent and SCID mice.西尼罗河病毒减毒株中活性神经侵袭性的丧失：在免疫健全和SCID小鼠中的致病性
Arch Virol. 1994;137(3-4):355-70. doi: 10.1007/BF01309481.
本文引用的文献
1
Composition of artificially produced and naturally occurring empty capsids of poliovirus type 1.1型脊髓灰质炎病毒人工制备及天然存在的空衣壳的组成
Virology. 1967 Aug;32(4):692-9. doi: 10.1016/0042-6822(67)90045-1.
2
THE EARLY INTERACTION OF ANIMAL VIRUSES AND CELLS.动物病毒与细胞的早期相互作用
Prog Med Virol. 1963;5:43-78.
3
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.流感病毒血凝素膜糖蛋白在3埃分辨率下的结构
Nature. 1981 Jan 29;289(5796):366-73. doi: 10.1038/289366a0.
4
Molecular basis of reovirus virulence. Role of the M2 gene.呼肠孤病毒毒力的分子基础。M2基因的作用。
J Exp Med. 1980 Oct 1;152(4):853-68. doi: 10.1084/jem.152.4.853.
5
Biochemical studies on the mechanism of chemical and physical inactivation of reovirus.呼肠孤病毒化学和物理灭活机制的生化研究
J Gen Virol. 1982 Nov;63 (Pt 1):161-70. doi: 10.1099/0022-1317-63-1-161.
6
Genetic studies on the mechanism of chemical and physical inactivation of reovirus.呼肠孤病毒化学和物理灭活机制的遗传学研究
J Gen Virol. 1982 Nov;63 (Pt 1):149-59. doi: 10.1099/0022-1317-63-1-149.
7
Is the acetylcholine receptor a rabies virus receptor?乙酰胆碱受体是狂犬病病毒受体吗？
Science. 1982 Jan 8;215(4529):182-4. doi: 10.1126/science.7053569.
8
Proteolytic activation of the influenza virus hemagglutinin: The structure of the cleavage site and the enzymes involved in cleavage.流感病毒血凝素的蛋白水解激活：裂解位点的结构及参与裂解的酶。
Virology. 1981 Dec;115(2):361-74. doi: 10.1016/0042-6822(81)90117-3.
9
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.在病毒介导的膜融合的最适pH值下流感病毒血凝素构象的变化
Proc Natl Acad Sci U S A. 1982 Feb;79(4):968-72. doi: 10.1073/pnas.79.4.968.
10
Molecular basis of rabies virus virulence. II. Identification of a site on the CVS glycoprotein associated with virulence.狂犬病病毒毒力的分子基础。II. 鉴定CVS糖蛋白上与毒力相关的位点。
J Gen Virol. 1983 Mar;64 Pt 3:693-6. doi: 10.1099/0022-1317-64-3-693.
Zotero 插件