嗜神经病毒感染的分子发病机制
Molecular pathogenesis of neurotropic viral infections.
作者信息
Gonzalez-Scarano F, Tyler K L
机构信息
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104.
出版信息
Ann Neurol. 1987 Nov;22(5):565-74. doi: 10.1002/ana.410220502.
Abstract
Classical virologists defined a number of viruses that affect the nervous system and identified tissue tropism, extraneural replication, and viremia as important parameters that determine whether viral infections will affect the central nervous system. Molecular techniques are expanding this knowledge by permitting us to relate specific genes and gene products to two defined phenotypes: neuroinvasion and neurovirulence. Two converging situations make this knowledge particularly useful: (1) the development of antiviral drugs and subunit vaccines, which mandate that pathogenesis be related to specific regions of the viral genome; and (2) the expanding problem of central nervous system infections in immunodeficient states.
摘要
传统病毒学家定义了多种影响神经系统的病毒，并确定了组织嗜性、神经外复制和病毒血症是决定病毒感染是否会影响中枢神经系统的重要参数。分子技术通过使我们能够将特定基因和基因产物与两种明确的表型（神经侵袭和神经毒力）联系起来，正在扩展这方面的知识。两种相互交织的情况使得这些知识尤为有用：（1）抗病毒药物和亚单位疫苗的研发，这要求发病机制与病毒基因组的特定区域相关；（2）免疫缺陷状态下中枢神经系统感染问题的不断扩大。
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