Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Am J Pathol. 2021 Feb;191(2):243-255. doi: 10.1016/j.ajpath.2020.11.007. Epub 2020 Dec 4.
Electronic nicotine delivery systems (often known as e-cigarettes) are a novel tobacco product with growing popularity, particularly among younger demographics. The implications for public health are twofold, as these products may represent a novel source of tobacco-associated disease but may also provide a harm reduction strategy for current tobacco users. There is increasing recognition that e-cigarettes impact vascular function across multiple organ systems. Herein, we provide a comparison of evidence regarding the role of e-cigarettes versus combustible tobacco in vascular disease and implications for blood-brain barrier dysfunction and cognitive decline. Multiple non-nicotinic components of tobacco smoke have been identified in e-cigarette aerosol, and their involvement in vascular disease is discussed. In addition, nicotine and nicotinic signaling may modulate peripheral immune and endothelial cell populations in a highly context-dependent manner. Direct preclinical evidence for electronic nicotine delivery system-associated neurovascular impairment is provided, and a model is proposed in which non-nicotinic elements exert a proinflammatory effect that is functionally antagonized by the presence of nicotine.
电子尼古丁传送系统（通常称为电子烟）是一种新型烟草产品，越来越受欢迎，尤其是在年轻人群中。这些产品对公共卫生的影响是双重的，因为它们可能代表了一种新的与烟草相关疾病的来源，但也可能为当前的烟草使用者提供一种减少危害的策略。人们越来越认识到，电子烟会影响多个器官系统的血管功能。在此，我们比较了电子烟与可燃烟草在血管疾病中的作用以及对血脑屏障功能障碍和认知能力下降的影响的证据。在电子烟气溶胶中已经鉴定出多种烟草烟雾的非尼古丁成分，并讨论了它们在血管疾病中的作用。此外，尼古丁和烟碱信号可能以高度依赖于上下文的方式调节外周免疫和内皮细胞群体。提供了与电子尼古丁传送系统相关的神经血管损伤的直接临床前证据，并提出了一种模型，其中非尼古丁成分发挥促炎作用，而尼古丁的存在则拮抗这种作用。
