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一种用于新型冠状病毒肺炎建模与模拟的分数阶方法。

A fractional order approach to modeling and simulations of the novel COVID-19.

作者信息

Owusu-Mensah Isaac, Akinyemi Lanre, Oduro Bismark, Iyiola Olaniyi S

机构信息

Department of Mathematics, Ohio University, Athens, Ohio USA.

Department of Science Education, University of Education, Winneba, Mampong-Ashanti Ghana.

出版信息

Adv Differ Equ. 2020;2020(1):683. doi: 10.1186/s13662-020-03141-7. Epub 2020 Dec 3.

Abstract

The novel coronavirus (SARS-CoV-2), or COVID-19, has emerged and spread at fast speed globally; the disease has become an unprecedented threat to public health worldwide. It is one of the greatest public health challenges in modern times, with no proven cure or vaccine. In this paper, our focus is on a fractional order approach to modeling and simulations of the novel COVID-19. We introduce a fractional type susceptible-exposed-infected-recovered (SEIR) model to gain insight into the ongoing pandemic. Our proposed model incorporates transmission rate, testing rates, and transition rate (from asymptomatic to symptomatic population groups) for a holistic study of the coronavirus disease. The impacts of these parameters on the dynamics of the solution profiles for the disease are simulated and discussed in detail. Furthermore, across all the different parameters, the effects of the fractional order derivative are also simulated and discussed in detail. Various simulations carried out enable us gain deep insights into the dynamics of the spread of COVID-19. The simulation results confirm that fractional calculus is an appropriate tool in modeling the spread of a complex infectious disease such as the novel COVID-19. In the absence of vaccine and treatment, our analysis strongly supports the significance reduction in the transmission rate as a valuable strategy to curb the spread of the virus. Our results suggest that tracing and moving testing up has an important benefit. It reduces the number of infected individuals in the general public and thereby reduces the spread of the pandemic. Once the infected individuals are identified and isolated, the interaction between susceptible and infected individuals diminishes and transmission reduces. Furthermore, aggressive testing is also highly recommended.

摘要

新型冠状病毒(SARS-CoV-2),即新冠病毒病(COVID-19),已在全球迅速出现并传播;该疾病已成为全球公共卫生面临的前所未有的威胁。它是现代最大的公共卫生挑战之一,尚无经证实的治愈方法或疫苗。在本文中,我们专注于用分数阶方法对新型新冠病毒病进行建模和模拟。我们引入一种分数阶易感-暴露-感染-康复(SEIR)模型,以深入了解当前的疫情。我们提出的模型纳入了传播率、检测率和转化率(从无症状人群到有症状人群组),以便对冠状病毒病进行全面研究。详细模拟并讨论了这些参数对疾病解曲线动态的影响。此外,针对所有不同参数,还详细模拟并讨论了分数阶导数的影响。所进行的各种模拟使我们能够深入了解新冠病毒病传播的动态。模拟结果证实,分数阶微积分是对新型新冠病毒病等复杂传染病传播进行建模的合适工具。在没有疫苗和治疗方法的情况下,我们的分析有力地支持将传播率显著降低作为遏制病毒传播的一项宝贵策略。我们的结果表明,追踪和提前进行流动检测有重要益处。它减少了普通公众中的感染个体数量,从而减少了疫情的传播。一旦识别并隔离了感染个体,易感个体与感染个体之间的相互作用就会减少,传播也会降低。此外,强烈建议进行积极检测。

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