胡椒甲醇提取物抗包虫囊原头蚴的体外潜在作用。
In vitro potential effect of Pipper longum methanolic extract against protoscolices of hydatid cysts.
机构信息
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Laboratory Sciences, School of Allied Medical Sciences, Lorestan University of Medical Sciences, Khorramabad, Iran.
出版信息
Exp Parasitol. 2021 Feb;221:108051. doi: 10.1016/j.exppara.2020.108051. Epub 2020 Dec 8.
This study aimed to evaluate the efficacy of methanolic extract of P. longum (PLM) against protoscolices of hydatid cyst in vitro. Four different concentrations of PLM extract (25, 50, 100 and 150 mg/ml) were used for the experiments. The metabolites in the PLM extract were characterized by Gas chromatography-mass spectrometry (GC-MS). The results showed the highest lethality of PLM extract in 50 mg/ml for 60 min exposure. The IC value obtained about 20 mg/ml for 60 min of PLM extract exposure. In this study, valuable findings were obtained for the first time about the scolicidal activity of P. longum, which is expected to conduct further studies in this field in the future.
本研究旨在评估马齿苋（PLM）甲醇提取物对体外包虫囊原头蚴的疗效。实验采用了四种不同浓度的 PLM 提取物（25、50、100 和 150mg/ml）。通过气相色谱-质谱联用（GC-MS）对 PLM 提取物中的代谢产物进行了表征。结果表明，在 50mg/ml 浓度下暴露 60 分钟时，PLM 提取物的致死率最高。暴露于 50mg/ml 的 PLM 提取物 60 分钟后，IC 值约为 20mg/ml。在这项研究中，首次获得了马齿苋杀囊尾蚴活性的有价值的发现，有望在未来进一步开展这一领域的研究。
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