Faculty of Chemistry, Bioanalysis Laboratory, University of Bialystok, Ciolkowskiego 1K, 15-245, Bialystok, Poland.
Poznan University of Technology, Faculty of Chemical Technology, Poland.
J Pharm Biomed Anal. 2021 Feb 5;194:113802. doi: 10.1016/j.jpba.2020.113802. Epub 2020 Nov 27.
A review is made of 71 papers on surface plasmon resonance biosensors, published between 2005 and 2020, mostly in the last decade. The reviewed papers are divided into two groups, depending on the validation of the developed biosensor. Validated biosensors are briefly characterized, while those that are not validated are listed in a table. Focus is placed on applications of SPR biosensors in testing the effectiveness of cancer markers and in the discovery of new cancer markers. Seven new markers are proposed, two of them having high sensitivity and diagnostic selectivity as determined by ROC curves. Papers concerning the determination of micro RNA and large particles such as vesicles, exosomes and cancer cells are also reviewed.
本文回顾了 2005 年至 2020 年间发表的 71 篇关于表面等离子体共振生物传感器的论文，其中大部分发表于过去十年。所回顾的论文分为两组，这取决于所开发的生物传感器的验证情况。对经过验证的生物传感器进行了简要描述，而未经过验证的则列在表中。本文重点介绍了 SPR 生物传感器在测试癌症标志物有效性和发现新的癌症标志物方面的应用。提出了 7 个新的标志物，其中两个标志物的 ROC 曲线显示具有较高的灵敏度和诊断选择性。本文还回顾了有关 micro RNA 和大颗粒（如囊泡、外泌体和癌细胞）测定的论文。
